Abnormal intrinsic and extrinsic connectivity within the magnetic mismatch negativity brain network in schizophrenia: a preliminary study

TY - JOUR

T1 - Abnormal intrinsic and extrinsic connectivity within the magnetic mismatch negativity brain network in schizophrenia

T2 - a preliminary study

AU - Dima, Danai

AU - Frangou, S

AU - Burge, L

AU - Braeutigam, S

AU - James, A C

N1 - Copyright © 2012 Elsevier B.V. All rights reserved.

PY - 2012/3

Y1 - 2012/3

N2 - Altered neuroplasticity is increasingly invoked as a mechanism underpinning dysconnectivity in schizophrenia. We used Dynamic Causal Modelling to compare connectivity during the magnetic auditory Mismatch Negativity (MMN), an index of error prediction, between schizophrenia patients and controls. Patients showed reduced intrinsic connectivity within the primary auditory cortex suggestive of impaired local neuronal adaptation and disrupted forward and backward extrinsic connectivity throughout the MMN network indicative of reduced higher order input in disambiguating activity in lower network nodes. Our study provides the first empirical description of the dysplastic changes underpinning dysconnectivity between primary sensory and higher order cortical areas in schizophrenia.

AB - Altered neuroplasticity is increasingly invoked as a mechanism underpinning dysconnectivity in schizophrenia. We used Dynamic Causal Modelling to compare connectivity during the magnetic auditory Mismatch Negativity (MMN), an index of error prediction, between schizophrenia patients and controls. Patients showed reduced intrinsic connectivity within the primary auditory cortex suggestive of impaired local neuronal adaptation and disrupted forward and backward extrinsic connectivity throughout the MMN network indicative of reduced higher order input in disambiguating activity in lower network nodes. Our study provides the first empirical description of the dysplastic changes underpinning dysconnectivity between primary sensory and higher order cortical areas in schizophrenia.

U2 - 10.1016/j.schres.2011.12.024

DO - 10.1016/j.schres.2011.12.024

M3 - Article

C2 - 22264684

SN - 1573-2509

VL - 135

SP - 23

EP - 27

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 1-3

ER -