Abnormal P300 in people with high risk of developing psychosis

Elvira Bramon; Madiha Shaikh; Matthew Broome; Julia Lappin; Daniel Bergé; Fern Day; James Woolley; Paul Tabraham; Mercè Madre; Louise Johns; Oliver Howes; Lucia Valmaggia; Víctor Pérez; Pak Sham; Robin M Murray; Philip McGuire

doi:10.1016/j.neuroimage.2007.12.038

Abnormal P300 in people with high risk of developing psychosis

Elvira Bramon^*, Madiha Shaikh, Matthew Broome, Julia Lappin, Daniel Bergé, Fern Day, James Woolley, Paul Tabraham, Mercè Madre, Louise Johns, Oliver Howes, Lucia Valmaggia, Víctor Pérez, Pak Sham, Robin M Murray, Philip McGuire

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

Background: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable.

Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression.

Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 +/- 6.4 microvolt] compared to controls [12.7 +/- 5.8 microvolt] (p <0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis.

Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other bio-logical markers may be of use to predict clinical outcomes in populations at high risk. (C) 2007 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	553-560
Number of pages	8
Journal	NeuroImage
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.neuroimage.2007.12.038
Publication status	Published - Jun 2008

Keywords

CORTICAL DYSFUNCTION
ULTRA-HIGH-RISK
AUDITORY P300
SCHIZOPHRENIA-PATIENTS
INITIAL PRODROMAL PHASE
DURATION MISMATCH NEGATIVITY
NEUROCOGNITIVE DEFICITS
RANDOMIZED CONTROLLED TRIAL
1ST-EPISODE PSYCHOSIS
EVENT-RELATED POTENTIALS

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10.1016/j.neuroimage.2007.12.038

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title = "Abnormal P300 in people with high risk of developing psychosis",

abstract = "Background: Individuals with an {"}at-risk mental state{"} (or {"}prodromal{"} symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable.Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression.Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 +/- 6.4 microvolt] compared to controls [12.7 +/- 5.8 microvolt] (p <0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis.Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other bio-logical markers may be of use to predict clinical outcomes in populations at high risk. (C) 2007 Elsevier Inc. All rights reserved.",

keywords = "CORTICAL DYSFUNCTION, ULTRA-HIGH-RISK, AUDITORY P300, SCHIZOPHRENIA-PATIENTS, INITIAL PRODROMAL PHASE, DURATION MISMATCH NEGATIVITY, NEUROCOGNITIVE DEFICITS, RANDOMIZED CONTROLLED TRIAL, 1ST-EPISODE PSYCHOSIS, EVENT-RELATED POTENTIALS",

author = "Elvira Bramon and Madiha Shaikh and Matthew Broome and Julia Lappin and Daniel Berg{\'e} and Fern Day and James Woolley and Paul Tabraham and Merc{\`e} Madre and Louise Johns and Oliver Howes and Lucia Valmaggia and V{\'i}ctor P{\'e}rez and Pak Sham and Murray, {Robin M} and Philip McGuire",

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doi = "10.1016/j.neuroimage.2007.12.038",

language = "English",

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T1 - Abnormal P300 in people with high risk of developing psychosis

AU - Bramon, Elvira

AU - Shaikh, Madiha

AU - Broome, Matthew

AU - Lappin, Julia

AU - Bergé, Daniel

AU - Day, Fern

AU - Woolley, James

AU - Tabraham, Paul

AU - Madre, Mercè

AU - Johns, Louise

AU - Howes, Oliver

AU - Valmaggia, Lucia

AU - Pérez, Víctor

AU - Sham, Pak

AU - Murray, Robin M

AU - McGuire, Philip

PY - 2008/6

Y1 - 2008/6

N2 - Background: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable.Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression.Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 +/- 6.4 microvolt] compared to controls [12.7 +/- 5.8 microvolt] (p <0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis.Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other bio-logical markers may be of use to predict clinical outcomes in populations at high risk. (C) 2007 Elsevier Inc. All rights reserved.

AB - Background: Individuals with an "at-risk mental state" (or "prodromal" symptoms) have a 20-40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable.Method: 35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression.Results: The P300 amplitude was significantly reduced in the ARMS group [8.6 +/- 6.4 microvolt] compared to controls [12.7 +/- 5.8 microvolt] (p <0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis.Conclusion: Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other bio-logical markers may be of use to predict clinical outcomes in populations at high risk. (C) 2007 Elsevier Inc. All rights reserved.

KW - CORTICAL DYSFUNCTION

KW - ULTRA-HIGH-RISK

KW - AUDITORY P300

KW - SCHIZOPHRENIA-PATIENTS

KW - INITIAL PRODROMAL PHASE

KW - DURATION MISMATCH NEGATIVITY

KW - NEUROCOGNITIVE DEFICITS

KW - RANDOMIZED CONTROLLED TRIAL

KW - 1ST-EPISODE PSYCHOSIS

KW - EVENT-RELATED POTENTIALS

U2 - 10.1016/j.neuroimage.2007.12.038

DO - 10.1016/j.neuroimage.2007.12.038

M3 - Article

C2 - 18387827

SN - 1053-8119

VL - 41

SP - 553

EP - 560

JO - NeuroImage

JF - NeuroImage

IS - 2

ER -

Abnormal P300 in people with high risk of developing psychosis

Abstract

Keywords

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