King's College London

Research portal

Abnormal temporal lobe morphology in asymptomatic relatives of patients with hippocampal sclerosis: a replication study

Research output: Contribution to journalArticle

Siti Nurbaya Yaakub, Gareth J. Barker, Sarah J. Carr, Eugenio Abela, Michalis Koutroumanidis, Robert D. C. Elwes, Mark P. Richardson

Original languageEnglish
JournalEpilepsia
Early online date16 Oct 2018
DOIs
Publication statusPublished - 16 Oct 2018

Documents

King's Authors

Abstract

We investigated gray and white matter morphology in patients with mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE+HS) and first‐degree asymptomatic relatives of patients with mTLE+HS. Using T1‐weighted magnetic resonance imaging (MRI), we sought to replicate previously reported findings of structural surface abnormalities of the anterior temporal lobe in asymptomatic relatives of patients with mTLE+HS in an independent cohort. We performed whole‐brain MRI in 19 patients with mTLE+HS, 14 first‐degree asymptomatic relatives of mTLE+HS patients, and 32 healthy control participants. Structural alterations in patients and relatives compared to controls were assessed using automated hippocampal volumetry and cortical surface–based morphometry. We replicated previously reported cortical surface area contractions in the ipsilateral anterior temporal lobe in both patients and relatives compared to healthy controls, with asymptomatic relatives showing similar but less extensive changes than patients. These findings suggest morphologic abnormality in asymptomatic relatives of mTLE+HS patients, suggesting an inherited brain structure endophenotype.

Download statistics

No data available

View graph of relations

© 2018 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454