Abnormalities of Resting State Functional Cortical Connectivity In Patients With Dementia Due To Alzheimer's and Lewy Body Diseases: An Eeg Study

Claudio Babiloni; Claudio Del Percio; Roberta Lizio; Giuseppe Noce; Susanna Lopez; Andrea Soricelli; Raffaele Ferri; Flavio Nobili; Dario Arnaldi; Francesco Famà; Dag Aarsland; Francesco Orzi; Carla Buttinelli; Franco Giubilei; Marco Onofrj; Fabrizio Stocchi; Paola Stirpe; Peter Fuhr; Ute Gschwandtner; Gerhard Ransmayr; Heinrich Garn; Lucia Fraioli; Michela Pievani; Giovanni B. Frisoni; Fabrizia D'Antonio; Carlo De Lena; Bahar Güntekin; Lutfu Hanoğlu; Erol Başar; Görsev Yener; Derya Durusu Emek-Savaş; Antonio Ivano Triggiani; Raffaella Franciotti; John Paul Taylor; Laura Vacca; Maria Francesca De Pandis; Laura Bonanni

doi:10.1016/j.neurobiolaging.2017.12.023

Abnormalities of Resting State Functional Cortical Connectivity In Patients With Dementia Due To Alzheimer's and Lewy Body Diseases: An Eeg Study

Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Andrea Soricelli, Raffaele Ferri, Flavio Nobili, Dario Arnaldi, Francesco Famà, Dag Aarsland, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Onofrj, Fabrizio Stocchi, Paola Stirpe, Peter Fuhr, Ute Gschwandtner, Gerhard RansmayrHeinrich Garn, Lucia Fraioli, Michela Pievani, Giovanni B. Frisoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Erol Başar, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, Raffaella Franciotti, John Paul Taylor, Laura Vacca, Maria Francesca De Pandis, Laura Bonanni

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Abstract

Previous evidence showed abnormal posterior sources of resting state delta (<4Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer’s disease with dementia (ADD), Parkinson’s disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a “disconnection cortical syndrome”, in comparison with PDD and DLB. Resting state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Nold) participants. eLORETA freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. Area under Receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values > 0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD vs. Nold individuals (0.84) than for DLB vs. Nold (0.78) and PDD vs. Nold (0.75). Functional cortical connectivity” markers in delta and alpha sources suggest a more compromised neurophysiological reserve in Alzheimer’s than Lewy body dementia, at both group and individual levels.

Original language	English
Journal	Neurobiology of Aging
Early online date	30 Dec 2017
DOIs	https://doi.org/10.1016/j.neurobiolaging.2017.12.023
Publication status	E-pub ahead of print - 30 Dec 2017

Keywords

Functional brain connectivity
Resting state EEG rhythms
Neurodegenerative diseases
Dementia
Alzheimer’s disease
Parkinson’s disease
Dementia with Lewy Bodies

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Abnormalities of Resting State_BABILONI_Publishedonline30December2017_GREEN AAM (CC BY-NC-ND)Accepted author manuscript, 1.6 MBLicence: CC BY-NC-ND

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Babiloni, C., Del Percio, C., Lizio, R., Noce, G., Lopez, S., Soricelli, A., Ferri, R., Nobili, F., Arnaldi, D., Famà, F., Aarsland, D., Orzi, F., Buttinelli, C., Giubilei, F., Onofrj, M., Stocchi, F., Stirpe, P., Fuhr, P., Gschwandtner, U., ... Bonanni, L. (2017). Abnormalities of Resting State Functional Cortical Connectivity In Patients With Dementia Due To Alzheimer's and Lewy Body Diseases: An Eeg Study. Neurobiology of Aging. Advance online publication. https://doi.org/10.1016/j.neurobiolaging.2017.12.023

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title = "Abnormalities of Resting State Functional Cortical Connectivity In Patients With Dementia Due To Alzheimer's and Lewy Body Diseases: An Eeg Study",

abstract = "Previous evidence showed abnormal posterior sources of resting state delta (<4Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer{\textquoteright}s disease with dementia (ADD), Parkinson{\textquoteright}s disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a “disconnection cortical syndrome”, in comparison with PDD and DLB. Resting state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Nold) participants. eLORETA freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. Area under Receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values > 0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD vs. Nold individuals (0.84) than for DLB vs. Nold (0.78) and PDD vs. Nold (0.75). Functional cortical connectivity” markers in delta and alpha sources suggest a more compromised neurophysiological reserve in Alzheimer{\textquoteright}s than Lewy body dementia, at both group and individual levels.",

keywords = "Functional brain connectivity, Resting state EEG rhythms, Neurodegenerative diseases, Dementia, Alzheimer{\textquoteright}s disease, Parkinson{\textquoteright}s disease, Dementia with Lewy Bodies",

author = "Claudio Babiloni and {Del Percio}, Claudio and Roberta Lizio and Giuseppe Noce and Susanna Lopez and Andrea Soricelli and Raffaele Ferri and Flavio Nobili and Dario Arnaldi and Francesco Fam{\`a} and Dag Aarsland and Francesco Orzi and Carla Buttinelli and Franco Giubilei and Marco Onofrj and Fabrizio Stocchi and Paola Stirpe and Peter Fuhr and Ute Gschwandtner and Gerhard Ransmayr and Heinrich Garn and Lucia Fraioli and Michela Pievani and Frisoni, {Giovanni B.} and Fabrizia D'Antonio and {De Lena}, Carlo and Bahar G{\"u}ntekin and Lutfu Hanoğlu and Erol Ba{\c s}ar and G{\"o}rsev Yener and Emek-Sava{\c s}, {Derya Durusu} and Triggiani, {Antonio Ivano} and Raffaella Franciotti and Taylor, {John Paul} and Laura Vacca and {De Pandis}, {Maria Francesca} and Laura Bonanni",

year = "2017",

month = dec,

day = "30",

doi = "10.1016/j.neurobiolaging.2017.12.023",

language = "English",

journal = "Neurobiology of Aging",

issn = "0197-4580",

publisher = "Elsevier B.V.",

}

Babiloni, C, Del Percio, C, Lizio, R, Noce, G, Lopez, S, Soricelli, A, Ferri, R, Nobili, F, Arnaldi, D, Famà, F, Aarsland, D, Orzi, F, Buttinelli, C, Giubilei, F, Onofrj, M, Stocchi, F, Stirpe, P, Fuhr, P, Gschwandtner, U, Ransmayr, G, Garn, H, Fraioli, L, Pievani, M, Frisoni, GB, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Başar, E, Yener, G, Emek-Savaş, DD, Triggiani, AI, Franciotti, R, Taylor, JP, Vacca, L, De Pandis, MF & Bonanni, L 2017, 'Abnormalities of Resting State Functional Cortical Connectivity In Patients With Dementia Due To Alzheimer's and Lewy Body Diseases: An Eeg Study', Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2017.12.023

TY - JOUR

T1 - Abnormalities of Resting State Functional Cortical Connectivity In Patients With Dementia Due To Alzheimer's and Lewy Body Diseases

T2 - An Eeg Study

AU - Babiloni, Claudio

AU - Del Percio, Claudio

AU - Lizio, Roberta

AU - Noce, Giuseppe

AU - Lopez, Susanna

AU - Soricelli, Andrea

AU - Ferri, Raffaele

AU - Nobili, Flavio

AU - Arnaldi, Dario

AU - Famà, Francesco

AU - Aarsland, Dag

AU - Orzi, Francesco

AU - Buttinelli, Carla

AU - Giubilei, Franco

AU - Onofrj, Marco

AU - Stocchi, Fabrizio

AU - Stirpe, Paola

AU - Fuhr, Peter

AU - Gschwandtner, Ute

AU - Ransmayr, Gerhard

AU - Garn, Heinrich

AU - Fraioli, Lucia

AU - Pievani, Michela

AU - Frisoni, Giovanni B.

AU - D'Antonio, Fabrizia

AU - De Lena, Carlo

AU - Güntekin, Bahar

AU - Hanoğlu, Lutfu

AU - Başar, Erol

AU - Yener, Görsev

AU - Emek-Savaş, Derya Durusu

AU - Triggiani, Antonio Ivano

AU - Franciotti, Raffaella

AU - Taylor, John Paul

AU - Vacca, Laura

AU - De Pandis, Maria Francesca

AU - Bonanni, Laura

PY - 2017/12/30

Y1 - 2017/12/30

N2 - Previous evidence showed abnormal posterior sources of resting state delta (<4Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer’s disease with dementia (ADD), Parkinson’s disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a “disconnection cortical syndrome”, in comparison with PDD and DLB. Resting state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Nold) participants. eLORETA freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. Area under Receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values > 0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD vs. Nold individuals (0.84) than for DLB vs. Nold (0.78) and PDD vs. Nold (0.75). Functional cortical connectivity” markers in delta and alpha sources suggest a more compromised neurophysiological reserve in Alzheimer’s than Lewy body dementia, at both group and individual levels.

AB - Previous evidence showed abnormal posterior sources of resting state delta (<4Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer’s disease with dementia (ADD), Parkinson’s disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a “disconnection cortical syndrome”, in comparison with PDD and DLB. Resting state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Nold) participants. eLORETA freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. Area under Receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values > 0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD vs. Nold individuals (0.84) than for DLB vs. Nold (0.78) and PDD vs. Nold (0.75). Functional cortical connectivity” markers in delta and alpha sources suggest a more compromised neurophysiological reserve in Alzheimer’s than Lewy body dementia, at both group and individual levels.

KW - Functional brain connectivity

KW - Resting state EEG rhythms

KW - Neurodegenerative diseases

KW - Dementia

KW - Alzheimer’s disease

KW - Parkinson’s disease

KW - Dementia with Lewy Bodies

U2 - 10.1016/j.neurobiolaging.2017.12.023

DO - 10.1016/j.neurobiolaging.2017.12.023

M3 - Article

SN - 0197-4580

JO - Neurobiology of Aging

JF - Neurobiology of Aging

ER -

Abnormalities of Resting State Functional Cortical Connectivity In Patients With Dementia Due To Alzheimer's and Lewy Body Diseases: An Eeg Study

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Keywords

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