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Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms

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Maria Teresa Pascarelli, Claudio Del Percio, Maria Francesca De Pandis, Raffaele Ferri, Roberta Lizio, Giuseppe Noce, Susanna Lopez, Marco Rizzo, Andrea Soricelli, Flavio Nobili, Dario Arnaldi, Francesco Famà, Francesco Orzi, Carla Buttinelli, Franco Giubilei, Marco Salvetti, Virginia Cipollini, Raffaella Franciotti, Marco Onofri, Peter Fuhr & 21 more Ute Gschwandtner, Gerhard Ransmayr, Dag Aarsland, Lucilla Parnetti, Lucia Farotti, Moira Marizzoni, Fabrizia D'Antonio, Carlo De Lena, Bahar Güntekin, Lutfu Hanoğlu, Görsev Yener, Derya Durusu Emek-Savaş, Antonio Ivano Triggiani, John Paul Taylor, Ian McKeith, Fabrizio Stocchi, Laura Vacca, Harald Hampel, Giovanni B. Frisoni, Laura Bonanni, Claudio Babiloni

Original languageEnglish
Pages (from-to)2716-2731
Number of pages16
JournalClinical Neurophysiology
Volume131
Issue number11
DOIs
PublishedNov 2020

King's Authors

Abstract

Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.

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