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Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms

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Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies : Relation to clinical symptoms. / Pascarelli, Maria Teresa; Del Percio, Claudio; De Pandis, Maria Francesca; Ferri, Raffaele; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Rizzo, Marco; Soricelli, Andrea; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Salvetti, Marco; Cipollini, Virginia; Franciotti, Raffaella; Onofri, Marco; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Aarsland, Dag; Parnetti, Lucilla; Farotti, Lucia; Marizzoni, Moira; D'Antonio, Fabrizia; De Lena, Carlo; Güntekin, Bahar; Hanoğlu, Lutfu; Yener, Görsev; Emek-Savaş, Derya Durusu; Ivano Triggiani, Antonio; Paul Taylor, John; McKeith, Ian; Stocchi, Fabrizio; Vacca, Laura; Hampel, Harald; Frisoni, Giovanni B.; Bonanni, Laura; Babiloni, Claudio.

In: Clinical Neurophysiology, Vol. 131, No. 11, 11.2020, p. 2716-2731.

Research output: Contribution to journalArticle

Harvard

Pascarelli, MT, Del Percio, C, De Pandis, MF, Ferri, R, Lizio, R, Noce, G, Lopez, S, Rizzo, M, Soricelli, A, Nobili, F, Arnaldi, D, Famà, F, Orzi, F, Buttinelli, C, Giubilei, F, Salvetti, M, Cipollini, V, Franciotti, R, Onofri, M, Fuhr, P, Gschwandtner, U, Ransmayr, G, Aarsland, D, Parnetti, L, Farotti, L, Marizzoni, M, D'Antonio, F, De Lena, C, Güntekin, B, Hanoğlu, L, Yener, G, Emek-Savaş, DD, Ivano Triggiani, A, Paul Taylor, J, McKeith, I, Stocchi, F, Vacca, L, Hampel, H, Frisoni, GB, Bonanni, L & Babiloni, C 2020, 'Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms', Clinical Neurophysiology, vol. 131, no. 11, pp. 2716-2731. https://doi.org/10.1016/j.clinph.2020.09.004

APA

Pascarelli, M. T., Del Percio, C., De Pandis, M. F., Ferri, R., Lizio, R., Noce, G., Lopez, S., Rizzo, M., Soricelli, A., Nobili, F., Arnaldi, D., Famà, F., Orzi, F., Buttinelli, C., Giubilei, F., Salvetti, M., Cipollini, V., Franciotti, R., Onofri, M., ... Babiloni, C. (2020). Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms. Clinical Neurophysiology, 131(11), 2716-2731. https://doi.org/10.1016/j.clinph.2020.09.004

Vancouver

Pascarelli MT, Del Percio C, De Pandis MF, Ferri R, Lizio R, Noce G et al. Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms. Clinical Neurophysiology. 2020 Nov;131(11):2716-2731. https://doi.org/10.1016/j.clinph.2020.09.004

Author

Pascarelli, Maria Teresa ; Del Percio, Claudio ; De Pandis, Maria Francesca ; Ferri, Raffaele ; Lizio, Roberta ; Noce, Giuseppe ; Lopez, Susanna ; Rizzo, Marco ; Soricelli, Andrea ; Nobili, Flavio ; Arnaldi, Dario ; Famà, Francesco ; Orzi, Francesco ; Buttinelli, Carla ; Giubilei, Franco ; Salvetti, Marco ; Cipollini, Virginia ; Franciotti, Raffaella ; Onofri, Marco ; Fuhr, Peter ; Gschwandtner, Ute ; Ransmayr, Gerhard ; Aarsland, Dag ; Parnetti, Lucilla ; Farotti, Lucia ; Marizzoni, Moira ; D'Antonio, Fabrizia ; De Lena, Carlo ; Güntekin, Bahar ; Hanoğlu, Lutfu ; Yener, Görsev ; Emek-Savaş, Derya Durusu ; Ivano Triggiani, Antonio ; Paul Taylor, John ; McKeith, Ian ; Stocchi, Fabrizio ; Vacca, Laura ; Hampel, Harald ; Frisoni, Giovanni B. ; Bonanni, Laura ; Babiloni, Claudio. / Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies : Relation to clinical symptoms. In: Clinical Neurophysiology. 2020 ; Vol. 131, No. 11. pp. 2716-2731.

Bibtex Download

@article{2819414c642a4c31a6af5ee21ba149bf,
title = "Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies: Relation to clinical symptoms",
abstract = "Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.",
keywords = "Exact low-resolution brain electromagnetic source tomography (eLORETA), Mild cognitive impairment (MCI), Prodromal and overt dementia with Lewy bodies (DLB), Rapid eye movement sleep behavior disorders (RBD), Resting state electroencephalographic (EEG) rhythms, Visual hallucinations",
author = "Pascarelli, {Maria Teresa} and {Del Percio}, Claudio and {De Pandis}, {Maria Francesca} and Raffaele Ferri and Roberta Lizio and Giuseppe Noce and Susanna Lopez and Marco Rizzo and Andrea Soricelli and Flavio Nobili and Dario Arnaldi and Francesco Fam{\`a} and Francesco Orzi and Carla Buttinelli and Franco Giubilei and Marco Salvetti and Virginia Cipollini and Raffaella Franciotti and Marco Onofri and Peter Fuhr and Ute Gschwandtner and Gerhard Ransmayr and Dag Aarsland and Lucilla Parnetti and Lucia Farotti and Moira Marizzoni and Fabrizia D'Antonio and {De Lena}, Carlo and Bahar G{\"u}ntekin and Lutfu Hanoğlu and G{\"o}rsev Yener and Emek-Sava{\c s}, {Derya Durusu} and {Ivano Triggiani}, Antonio and {Paul Taylor}, John and Ian McKeith and Fabrizio Stocchi and Laura Vacca and Harald Hampel and Frisoni, {Giovanni B.} and Laura Bonanni and Claudio Babiloni",
year = "2020",
month = nov,
doi = "10.1016/j.clinph.2020.09.004",
language = "English",
volume = "131",
pages = "2716--2731",
journal = "Clinical Neurophysiology",
issn = "1388-2457",
publisher = "Elsevier Ireland Ltd",
number = "11",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Abnormalities of resting-state EEG in patients with prodromal and overt dementia with Lewy bodies

T2 - Relation to clinical symptoms

AU - Pascarelli, Maria Teresa

AU - Del Percio, Claudio

AU - De Pandis, Maria Francesca

AU - Ferri, Raffaele

AU - Lizio, Roberta

AU - Noce, Giuseppe

AU - Lopez, Susanna

AU - Rizzo, Marco

AU - Soricelli, Andrea

AU - Nobili, Flavio

AU - Arnaldi, Dario

AU - Famà, Francesco

AU - Orzi, Francesco

AU - Buttinelli, Carla

AU - Giubilei, Franco

AU - Salvetti, Marco

AU - Cipollini, Virginia

AU - Franciotti, Raffaella

AU - Onofri, Marco

AU - Fuhr, Peter

AU - Gschwandtner, Ute

AU - Ransmayr, Gerhard

AU - Aarsland, Dag

AU - Parnetti, Lucilla

AU - Farotti, Lucia

AU - Marizzoni, Moira

AU - D'Antonio, Fabrizia

AU - De Lena, Carlo

AU - Güntekin, Bahar

AU - Hanoğlu, Lutfu

AU - Yener, Görsev

AU - Emek-Savaş, Derya Durusu

AU - Ivano Triggiani, Antonio

AU - Paul Taylor, John

AU - McKeith, Ian

AU - Stocchi, Fabrizio

AU - Vacca, Laura

AU - Hampel, Harald

AU - Frisoni, Giovanni B.

AU - Bonanni, Laura

AU - Babiloni, Claudio

PY - 2020/11

Y1 - 2020/11

N2 - Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.

AB - Objective: Here we tested if cortical sources of resting state electroencephalographic (rsEEG) rhythms may differ in sub-groups of patients with prodromal and overt dementia with Lewy bodies (DLB) as a function of relevant clinical symptoms. Methods: We extracted clinical, demographic and rsEEG datasets in matched DLB patients (N = 60) and control Alzheimer's disease (AD, N = 60) and healthy elderly (Nold, N = 60) seniors from our international database. The eLORETA freeware was used to estimate cortical rsEEG sources. Results: As compared to the Nold group, the DLB and AD groups generally exhibited greater spatially distributed delta source activities (DLB > AD) and lower alpha source activities posteriorly (AD > DLB). As compared to the DLB “controls”, the DLB patients with (1) rapid eye movement (REM) sleep behavior disorders showed lower central alpha source activities (p < 0.005); (2) greater cognitive deficits exhibited higher parietal and central theta source activities as well as higher central, parietal, and occipital alpha source activities (p < 0.01); (3) visual hallucinations pointed to greater parietal delta source activities (p < 0.005). Conclusions: Relevant clinical features were associated with abnormalities in spatial and frequency features of rsEEG source activities in DLB patients. Significance: Those features may be used as neurophysiological surrogate endpoints of clinical symptoms in DLB patients in future cross-validation prospective studies.

KW - Exact low-resolution brain electromagnetic source tomography (eLORETA)

KW - Mild cognitive impairment (MCI)

KW - Prodromal and overt dementia with Lewy bodies (DLB)

KW - Rapid eye movement sleep behavior disorders (RBD)

KW - Resting state electroencephalographic (EEG) rhythms

KW - Visual hallucinations

UR - http://www.scopus.com/inward/record.url?scp=85092140716&partnerID=8YFLogxK

U2 - 10.1016/j.clinph.2020.09.004

DO - 10.1016/j.clinph.2020.09.004

M3 - Article

AN - SCOPUS:85092140716

VL - 131

SP - 2716

EP - 2731

JO - Clinical Neurophysiology

JF - Clinical Neurophysiology

SN - 1388-2457

IS - 11

ER -

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