Absence of cholinergic deficits in "pure" vascular dementia

TY - JOUR

T1 - Absence of cholinergic deficits in "pure" vascular dementia

AU - Perry, E

AU - Ziabreva, I

AU - Perry, R

AU - Aarsland, D

AU - Ballard, C

PY - 2005

Y1 - 2005

N2 - Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases ( 9 vascular dementia [VaD] cases, 12 "mixed" VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and "mixed" VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients.

AB - Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases ( 9 vascular dementia [VaD] cases, 12 "mixed" VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and "mixed" VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients.

M3 - Article

SN - 1526-632X

VL - 64

SP - 132

EP - 133

JO - Neurology

JF - Neurology

IS - 1

ER -