Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study

Michael Eyre; Michael Absoud; Omar Abdel-Mannan; Sarah Crichton; Yael Hacohen; Thomas Rossor; Sarah Rudebeck; Gavin Giovannoni; Ming Lim; Cheryl Hemingway

doi:10.1002/acn3.52198

Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study

Michael Eyre^*, Michael Absoud, Omar Abdel-Mannan, Sarah Crichton, Yael Hacohen, Thomas Rossor, Sarah Rudebeck, Gavin Giovannoni, Ming Lim, Cheryl Hemingway

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

It is unknown if cognition is impaired before clinical onset of paediatric acquired demyelinating syndromes. We conducted a matched cohort study using prospectively collected educational data in multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) patients (n = 60) and controls (pooled n = 449,553). Academic performance at ages 10–11 was impaired in MOGAD (−1.27 adjusted z-score [95% CI: −1.81 to −0.73], P < 0.001) and preclinical MS (−0.40 [−0.80 to −0.0003], P = 0.0498). Moderate/high-efficacy MS treatment was associated with better final academic performance (0.92 [0.28–1.57], P = 0.005). After clinical onset MS patients missed 8.7% of school (controls 2.9%, P < 0.001) and MOGAD patients 11.9% (controls 2.0%, P < 0.001).

Original language	English
Pages (from-to)	3025-3030
Number of pages	6
Journal	Annals of Clinical and Translational Neurology
Volume	11
Issue number	11
DOIs	https://doi.org/10.1002/acn3.52198
Publication status	Published - Nov 2024

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Eyre, M., Absoud, M., Abdel-Mannan, O., Crichton, S., Hacohen, Y., Rossor, T., Rudebeck, S., Giovannoni, G., Lim, M., & Hemingway, C. (2024). Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study. Annals of Clinical and Translational Neurology, 11(11), 3025-3030. https://doi.org/10.1002/acn3.52198

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title = "Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study",

abstract = "It is unknown if cognition is impaired before clinical onset of paediatric acquired demyelinating syndromes. We conducted a matched cohort study using prospectively collected educational data in multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) patients (n = 60) and controls (pooled n = 449,553). Academic performance at ages 10–11 was impaired in MOGAD (−1.27 adjusted z-score [95% CI: −1.81 to −0.73], P < 0.001) and preclinical MS (−0.40 [−0.80 to −0.0003], P = 0.0498). Moderate/high-efficacy MS treatment was associated with better final academic performance (0.92 [0.28–1.57], P = 0.005). After clinical onset MS patients missed 8.7% of school (controls 2.9%, P < 0.001) and MOGAD patients 11.9% (controls 2.0%, P < 0.001).",

author = "Michael Eyre and Michael Absoud and Omar Abdel-Mannan and Sarah Crichton and Yael Hacohen and Thomas Rossor and Sarah Rudebeck and Gavin Giovannoni and Ming Lim and Cheryl Hemingway",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.",

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Eyre, M , Absoud, M, Abdel-Mannan, O, Crichton, S, Hacohen, Y, Rossor, T, Rudebeck, S, Giovannoni, G, Lim, M & Hemingway, C 2024, 'Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study', Annals of Clinical and Translational Neurology, vol. 11, no. 11, pp. 3025-3030. https://doi.org/10.1002/acn3.52198

TY - JOUR

T1 - Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children

T2 - a matched cohort data linkage study

AU - Eyre, Michael

AU - Absoud, Michael

AU - Abdel-Mannan, Omar

AU - Crichton, Sarah

AU - Hacohen, Yael

AU - Rossor, Thomas

AU - Rudebeck, Sarah

AU - Giovannoni, Gavin

AU - Lim, Ming

AU - Hemingway, Cheryl

PY - 2024/11

Y1 - 2024/11

N2 - It is unknown if cognition is impaired before clinical onset of paediatric acquired demyelinating syndromes. We conducted a matched cohort study using prospectively collected educational data in multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) patients (n = 60) and controls (pooled n = 449,553). Academic performance at ages 10–11 was impaired in MOGAD (−1.27 adjusted z-score [95% CI: −1.81 to −0.73], P < 0.001) and preclinical MS (−0.40 [−0.80 to −0.0003], P = 0.0498). Moderate/high-efficacy MS treatment was associated with better final academic performance (0.92 [0.28–1.57], P = 0.005). After clinical onset MS patients missed 8.7% of school (controls 2.9%, P < 0.001) and MOGAD patients 11.9% (controls 2.0%, P < 0.001).

AB - It is unknown if cognition is impaired before clinical onset of paediatric acquired demyelinating syndromes. We conducted a matched cohort study using prospectively collected educational data in multiple sclerosis (MS) and myelin oligodendrocyte glycoprotein antibody disease (MOGAD) patients (n = 60) and controls (pooled n = 449,553). Academic performance at ages 10–11 was impaired in MOGAD (−1.27 adjusted z-score [95% CI: −1.81 to −0.73], P < 0.001) and preclinical MS (−0.40 [−0.80 to −0.0003], P = 0.0498). Moderate/high-efficacy MS treatment was associated with better final academic performance (0.92 [0.28–1.57], P = 0.005). After clinical onset MS patients missed 8.7% of school (controls 2.9%, P < 0.001) and MOGAD patients 11.9% (controls 2.0%, P < 0.001).

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ER -

Academic outcomes before and after clinical onset of acquired demyelinating syndromes in children: a matched cohort data linkage study

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