Accelerated forgetting in temporal lobe epilepsy: When does it occur?

Israel Contador; Abraham Sánchez; Michael D. Kopelman; Jesús González de la Aleja; Pablo Ruisoto

doi:10.1016/j.cortex.2021.03.035

Accelerated forgetting in temporal lobe epilepsy: When does it occur?

Israel Contador^*, Abraham Sánchez, Michael D. Kopelman, Jesús González de la Aleja, Pablo Ruisoto

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Objective: The main goal of the study was to analyse differences in the forgetting rates of Temporal Lobe Epilepsy (TLE) patients at different intervals (30 sec, 10 min, 1 day and 1 week) compared with those of healthy controls. A secondary aim of this research was to provide an assessment of the relationship between clinical epilepsy-related variables and forgetting rates in TLE patients. Method: The sample was composed of 14 TLE patients and 14 healthy matched controls. All participants underwent a full standardised neuropsychological assessment including general intelligence, executive functioning, memory, language and other variables, such as depression, anxiety or everyday memory failures. Two specific memory tasks, consisting of cued recall of 4 short stories and 4 routes, were carried out at four different intervals. Results: There was a significant difference between groups at 10-min interval on the stories task, with the TLE group displaying greater forgetting than healthy controls. None of the other intervals on either task showed significant group differences. No differences were found when controlling for clinical epilepsy-related variables. Conclusion: Forgetting of verbal information at 10 min was greater in patients with TLE compared with controls, but accelerated longer term forgetting was not found. This study suggests that a late consolidation process is not necessarily impaired in TLE patients.

Original language	English
Pages (from-to)	190-200
Number of pages	11
Journal	Cortex
Volume	141
DOIs	https://doi.org/10.1016/j.cortex.2021.03.035
Publication status	Published - Aug 2021

Keywords

Accelerated long-term forgetting
Forgetting
Memory consolidation
Temporal lobe epilepsy

Access to Document

10.1016/j.cortex.2021.03.035

Cite this

@article{0fadefaae5e147b2ab7a3274de65e493,

title = "Accelerated forgetting in temporal lobe epilepsy: When does it occur?",

abstract = "Objective: The main goal of the study was to analyse differences in the forgetting rates of Temporal Lobe Epilepsy (TLE) patients at different intervals (30 sec, 10 min, 1 day and 1 week) compared with those of healthy controls. A secondary aim of this research was to provide an assessment of the relationship between clinical epilepsy-related variables and forgetting rates in TLE patients. Method: The sample was composed of 14 TLE patients and 14 healthy matched controls. All participants underwent a full standardised neuropsychological assessment including general intelligence, executive functioning, memory, language and other variables, such as depression, anxiety or everyday memory failures. Two specific memory tasks, consisting of cued recall of 4 short stories and 4 routes, were carried out at four different intervals. Results: There was a significant difference between groups at 10-min interval on the stories task, with the TLE group displaying greater forgetting than healthy controls. None of the other intervals on either task showed significant group differences. No differences were found when controlling for clinical epilepsy-related variables. Conclusion: Forgetting of verbal information at 10 min was greater in patients with TLE compared with controls, but accelerated longer term forgetting was not found. This study suggests that a late consolidation process is not necessarily impaired in TLE patients.",

keywords = "Accelerated long-term forgetting, Forgetting, Memory consolidation, Temporal lobe epilepsy",

author = "Israel Contador and Abraham S{\'a}nchez and Kopelman, {Michael D.} and {Gonz{\'a}lez de la Aleja}, Jes{\'u}s and Pablo Ruisoto",

note = "Funding Information: Israel Contador was supported by a post-doc fellowship (JC 2011-0012) from the Spanish Ministry of Education . We have reported how we determined our sample size, all data exclusions (if any), all inclusion/exclusion criteria, whether inclusion/exclusion criteria were established prior to data analysis, all manipulations, and all measures in the study (see methods). The conditions of the ethics approval do not permit public archiving of the study data. This information will be made available to researchers upon request. They should contact the lead author, following completion of a data sharing agreement and the approval by the ethics committee. No part of the study procedures or analyses was pre-registered prior to the research being conducted. Detailed examples of the experimental stimuli are available in supplementary material . Copyright restrictions prevent public archiving of the neuropsychological tests and questionnaires used in this study, which can be obtained from copyright holders (see cited references). Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

year = "2021",

month = aug,

doi = "10.1016/j.cortex.2021.03.035",

language = "English",

volume = "141",

pages = "190--200",

journal = "Cortex",

issn = "0010-9452",

publisher = "Elsevier Masson",

}

TY - JOUR

T1 - Accelerated forgetting in temporal lobe epilepsy

T2 - When does it occur?

AU - Contador, Israel

AU - Sánchez, Abraham

AU - Kopelman, Michael D.

AU - González de la Aleja, Jesús

AU - Ruisoto, Pablo

N1 - Funding Information: Israel Contador was supported by a post-doc fellowship (JC 2011-0012) from the Spanish Ministry of Education . We have reported how we determined our sample size, all data exclusions (if any), all inclusion/exclusion criteria, whether inclusion/exclusion criteria were established prior to data analysis, all manipulations, and all measures in the study (see methods). The conditions of the ethics approval do not permit public archiving of the study data. This information will be made available to researchers upon request. They should contact the lead author, following completion of a data sharing agreement and the approval by the ethics committee. No part of the study procedures or analyses was pre-registered prior to the research being conducted. Detailed examples of the experimental stimuli are available in supplementary material . Copyright restrictions prevent public archiving of the neuropsychological tests and questionnaires used in this study, which can be obtained from copyright holders (see cited references). Publisher Copyright: © 2021 Elsevier Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/8

Y1 - 2021/8

N2 - Objective: The main goal of the study was to analyse differences in the forgetting rates of Temporal Lobe Epilepsy (TLE) patients at different intervals (30 sec, 10 min, 1 day and 1 week) compared with those of healthy controls. A secondary aim of this research was to provide an assessment of the relationship between clinical epilepsy-related variables and forgetting rates in TLE patients. Method: The sample was composed of 14 TLE patients and 14 healthy matched controls. All participants underwent a full standardised neuropsychological assessment including general intelligence, executive functioning, memory, language and other variables, such as depression, anxiety or everyday memory failures. Two specific memory tasks, consisting of cued recall of 4 short stories and 4 routes, were carried out at four different intervals. Results: There was a significant difference between groups at 10-min interval on the stories task, with the TLE group displaying greater forgetting than healthy controls. None of the other intervals on either task showed significant group differences. No differences were found when controlling for clinical epilepsy-related variables. Conclusion: Forgetting of verbal information at 10 min was greater in patients with TLE compared with controls, but accelerated longer term forgetting was not found. This study suggests that a late consolidation process is not necessarily impaired in TLE patients.

AB - Objective: The main goal of the study was to analyse differences in the forgetting rates of Temporal Lobe Epilepsy (TLE) patients at different intervals (30 sec, 10 min, 1 day and 1 week) compared with those of healthy controls. A secondary aim of this research was to provide an assessment of the relationship between clinical epilepsy-related variables and forgetting rates in TLE patients. Method: The sample was composed of 14 TLE patients and 14 healthy matched controls. All participants underwent a full standardised neuropsychological assessment including general intelligence, executive functioning, memory, language and other variables, such as depression, anxiety or everyday memory failures. Two specific memory tasks, consisting of cued recall of 4 short stories and 4 routes, were carried out at four different intervals. Results: There was a significant difference between groups at 10-min interval on the stories task, with the TLE group displaying greater forgetting than healthy controls. None of the other intervals on either task showed significant group differences. No differences were found when controlling for clinical epilepsy-related variables. Conclusion: Forgetting of verbal information at 10 min was greater in patients with TLE compared with controls, but accelerated longer term forgetting was not found. This study suggests that a late consolidation process is not necessarily impaired in TLE patients.

KW - Accelerated long-term forgetting

KW - Forgetting

KW - Memory consolidation

KW - Temporal lobe epilepsy

UR - http://www.scopus.com/inward/record.url?scp=85106920154&partnerID=8YFLogxK

U2 - 10.1016/j.cortex.2021.03.035

DO - 10.1016/j.cortex.2021.03.035

M3 - Article

AN - SCOPUS:85106920154

SN - 0010-9452

VL - 141

SP - 190

EP - 200

JO - Cortex

JF - Cortex

ER -

Accelerated forgetting in temporal lobe epilepsy: When does it occur?

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this