Accelerated magnetic resonance fingerprinting using soft-weighted key-hole (MRF-SOHO)

TY - JOUR

T1 - Accelerated magnetic resonance fingerprinting using soft-weighted key-hole (MRF-SOHO)

AU - Lima da Cruz, Gastao Jose

AU - Schneider, Torben

AU - Bruijnen, Tom

AU - Gaspar, Andreia S

AU - Botnar, Rene Michael

AU - Prieto Vasquez, Claudia

PY - 2018/8/9

Y1 - 2018/8/9

N2 - OBJECT: To develop a novel approach for highly accelerated Magnetic Resonance Fingerprinting (MRF) acquisition.MATERIALS AND METHODS: The proposed method combines parallel imaging, soft-gating and key-hole approaches to highly accelerate MRF acquisition. Slowly varying flip angles (FA), commonly used during MRF acquisition, lead to a smooth change in the signal contrast of consecutive time-point images. This assumption enables sharing of high frequency data between different time-points, similar to what is done in some dynamic MR imaging methods such as key-hole. The proposed approach exploits this information using a SOft-weighted key-HOle (MRF-SOHO) reconstruction to achieve high acceleration factors and/or increased resolution without compromising image quality or increasing scan time. MRF-SOHO was validated on a standard T1/T2 phantom and in in-vivo brain acquisitions reconstructing T1, T2 and proton density parametric maps.RESULTS: Accelerated MRF-SOHO using less data per time-point and less time-point images enabled a considerable reduction in scan time (up to 4.6x), while obtaining similar T1 and T2 accuracy and precision when compared to zero-filled MRF reconstruction. For the same number of spokes and time-points, the proposed method yielded an enhanced performance in quantifying parameters than the zero-filled MRF reconstruction, which was verified with 2, 1 and 0.7 (sub-millimetre) resolutions.CONCLUSION: The proposed MRF-SOHO enabled a 4.6x scan time reduction for an in-plane spatial resolution of 2x2 mm2 when compared to zero-filled MRF and enabled sub-millimetric (0.7x0.7 mm2) resolution MRF.

AB - OBJECT: To develop a novel approach for highly accelerated Magnetic Resonance Fingerprinting (MRF) acquisition.MATERIALS AND METHODS: The proposed method combines parallel imaging, soft-gating and key-hole approaches to highly accelerate MRF acquisition. Slowly varying flip angles (FA), commonly used during MRF acquisition, lead to a smooth change in the signal contrast of consecutive time-point images. This assumption enables sharing of high frequency data between different time-points, similar to what is done in some dynamic MR imaging methods such as key-hole. The proposed approach exploits this information using a SOft-weighted key-HOle (MRF-SOHO) reconstruction to achieve high acceleration factors and/or increased resolution without compromising image quality or increasing scan time. MRF-SOHO was validated on a standard T1/T2 phantom and in in-vivo brain acquisitions reconstructing T1, T2 and proton density parametric maps.RESULTS: Accelerated MRF-SOHO using less data per time-point and less time-point images enabled a considerable reduction in scan time (up to 4.6x), while obtaining similar T1 and T2 accuracy and precision when compared to zero-filled MRF reconstruction. For the same number of spokes and time-points, the proposed method yielded an enhanced performance in quantifying parameters than the zero-filled MRF reconstruction, which was verified with 2, 1 and 0.7 (sub-millimetre) resolutions.CONCLUSION: The proposed MRF-SOHO enabled a 4.6x scan time reduction for an in-plane spatial resolution of 2x2 mm2 when compared to zero-filled MRF and enabled sub-millimetric (0.7x0.7 mm2) resolution MRF.

KW - MR fingerprinting

KW - accelerated MRF

KW - soft-weighting

KW - key-hole

UR - https://www.scopus.com/pages/publications/85052285765

U2 - 10.1371/journal.pone.0201808

DO - 10.1371/journal.pone.0201808

M3 - Article

C2 - 30092033

SN - 1932-6203

VL - 13

JO - PLoS ONE

JF - PLoS ONE

IS - 8

M1 - e0201808

ER -