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Accuracy and cost-effectiveness of dynamic contrast-enhanced CT in the characterisation of solitary pulmonary nodules — The SPUtNIk study

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N. R. Qureshi, R. C. Rintoul, K. A. Miles, S. George, S. Harris, J. Madden, K. Cozens, L. A. Little, K. Eichhorst, J. Jones, P. Moate, C. McClement, L.C. Pike, Donald Sinclair, W. L. Wong, J. Shekhdar, R. Eaton, A. Shah, L. Brindle, C. Peebles & 13 more A. Banerjee, S. Dizdarevic, S. Han, F. W. Poon, A. M. Groves, L. Kurban, A. J. Frew, M. E. Callister, P. Crosbie, F. V. Gleeson, K. Karunasaagarar, O. Kankam, F. J. Gilbert

Original languageEnglish
Article numbere000156
JournalBMJ Open Respiratory Research
Volume3
Issue number1
DOIs
Accepted/In press17 Aug 2016
Published14 Oct 2016

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Abstract

Introduction: Solitary pulmonary nodules (SPNs) are common on CT. The most cost-effective investigation algorithm is still to be determined. Dynamic contrastenhanced CT (DCE-CT) is an established diagnostic test not widely available in the UK currently. Methods and analysis: The SPUtNIk study will assess the diagnostic accuracy, clinical utility and costeffectiveness of DCE-CT, alongside the current CT and 18-flurodeoxyglucose-positron emission tomography) (18FDG-PET)-CT nodule characterisation strategies in the National Health Service (NHS). Image acquisition and data analysis for18FDG-PET-CT and DCE-CT will follow a standardised protocol with central review of 10% to ensure quality assurance. Decision analytic modelling will assess the likely costs and health outcomes resulting from incorporation of DCE-CT into management strategies for patients with SPNs. Ethics and dissemination: Approval has been granted by the South West Research Ethics Committee. Ethics reference number 12/SW/0206. The results of the trial will be presented at national and international meetings and published in an Health Technology Assessment (HTA) Monograph and in peer-reviewed journals.

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