Acetylcholinesterase inhibitors from plants and fungi

TY - JOUR

T1 - Acetylcholinesterase inhibitors from plants and fungi

AU - Houghton, P J

AU - Ren, Y H

AU - Howes, M J

PY - 2006

Y1 - 2006

N2 - This review describes 183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase. The mechanism of action of cholinesterase, together with the binding sites, and, where this is known, the mode of action of inhibitors is described. The relative activities of the different compounds are recorded. The strongest inhibitors are generally alkaloids although some meroterpenoids from fungi have also been found to be active and display better selectivity

AB - This review describes 183 compounds obtained from plants and fungi which have been shown to inhibit acetylcholinesterase. The mechanism of action of cholinesterase, together with the binding sites, and, where this is known, the mode of action of inhibitors is described. The relative activities of the different compounds are recorded. The strongest inhibitors are generally alkaloids although some meroterpenoids from fungi have also been found to be active and display better selectivity

U2 - 10.1039/b508966m

DO - 10.1039/b508966m

M3 - Literature review

VL - 23

SP - 181

EP - 199

JO - Natural Product Reports

JF - Natural Product Reports

IS - 2

ER -