Actin-Aggregating Cucurbitacins from Physocarpus capitatus

Katherine N. Maloney; Masaki Fujita; Ulrike Eggert; Frank C. Schroeder; Christine M. Field; Timothy J. Mitchison; Jon Clardy

doi:10.1021/np8005259

Actin-Aggregating Cucurbitacins from Physocarpus capitatus

Katherine N. Maloney, Masaki Fujita, Ulrike Eggert, Frank C. Schroeder, Christine M. Field, Timothy J. Mitchison, Jon Clardy

Harvard Medical School

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.

Original language	English
Pages (from-to)	1927-1929
Number of pages	3
Journal	Journal of Natural Products
Volume	71
Issue number	11
DOIs	https://doi.org/10.1021/np8005259
Publication status	Published - Nov 2008

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title = "Actin-Aggregating Cucurbitacins from Physocarpus capitatus",

abstract = "Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.",

author = "Maloney, {Katherine N.} and Masaki Fujita and Ulrike Eggert and Schroeder, {Frank C.} and Field, {Christine M.} and Mitchison, {Timothy J.} and Jon Clardy",

year = "2008",

month = nov,

doi = "10.1021/np8005259",

language = "English",

volume = "71",

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journal = "Journal of Natural Products",

issn = "0163-3864",

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T1 - Actin-Aggregating Cucurbitacins from Physocarpus capitatus

AU - Maloney, Katherine N.

AU - Fujita, Masaki

AU - Eggert, Ulrike

AU - Schroeder, Frank C.

AU - Field, Christine M.

AU - Mitchison, Timothy J.

AU - Clardy, Jon

PY - 2008/11

Y1 - 2008/11

N2 - Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.

AB - Bioassay-guided fractionation of Physocarpus capitatus yielded two new cucurbitacins (3 and 4) along with the known cucurbitacin F (1) and dihydrocucurbitacin F (2). Preliminary mechanism of action studies indicate that the cucurbitacins cause actin aggregates and inhibit cell division.

U2 - 10.1021/np8005259

DO - 10.1021/np8005259

M3 - Article

SN - 0163-3864

VL - 71

SP - 1927

EP - 1929

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 11

ER -

Actin-Aggregating Cucurbitacins from Physocarpus capitatus

Abstract

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