Actin in striated muscle: recent insights into assembly and maintenance

Research output: Contribution to journalLiterature reviewpeer-review

7 Citations (Scopus)

Abstract

Striated muscle cells are characterised by a para- crystalline arrangement of their contractile proteins actin and myosin in sarcomeres, the basic unit of the myofibrils. A multitude of proteins is required to build and maintain the structure of this regular arrangement as well as to ensure regulation of contraction and to respond to alterations in de- mand. This review focuses on the actin filaments (also called thin filaments) of the sarcomere and will discuss how they are assembled during myofibrillogenesis and in hypertrophy and how their integrity is maintained in the working myocardium.
Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalBiophysical Reviews
Volume4
Issue number1
DOIs
Publication statusPublished - Mar 2012

Keywords

  • Actin
  • Sarcomere
  • Myofibrillogenesis
  • Cardiomyopathy
  • Formin

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