Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase

David F. Burke; Charles A. Laughton; Chris F. Snook; Stephen Neidle; Gerard A. Potter; Michael Jarman

doi:10.1016/0960-894X(95)00178-V

Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase

David F. Burke^*, Charles A. Laughton, Chris F. Snook, Stephen Neidle, Gerard A. Potter, Michael Jarman

^*Corresponding author for this work

Centre for Host Microbiome Interactions

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

17-(3-pyridyl)androsta-5,16-dien-3β-ol, a nanomolar inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase, is a target for prostate cancer chemotherapy. A model is presented for the inhibitor docked into the structure of the enzyme.

Original language	English
Pages (from-to)	1125-1130
Number of pages	6
Journal	BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS
Volume	5
Issue number	11
DOIs	https://doi.org/10.1016/0960-894X(95)00178-V
Publication status	Published - 8 Jun 1995

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title = "Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase",

abstract = "17-(3-pyridyl)androsta-5,16-dien-3β-ol, a nanomolar inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase, is a target for prostate cancer chemotherapy. A model is presented for the inhibitor docked into the structure of the enzyme.",

author = "Burke, {David F.} and Laughton, {Charles A.} and Snook, {Chris F.} and Stephen Neidle and Potter, {Gerard A.} and Michael Jarman",

year = "1995",

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T1 - Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase

AU - Burke, David F.

AU - Laughton, Charles A.

AU - Snook, Chris F.

AU - Neidle, Stephen

AU - Potter, Gerard A.

AU - Jarman, Michael

PY - 1995/6/8

Y1 - 1995/6/8

N2 - 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a nanomolar inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase, is a target for prostate cancer chemotherapy. A model is presented for the inhibitor docked into the structure of the enzyme.

AB - 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a nanomolar inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase, is a target for prostate cancer chemotherapy. A model is presented for the inhibitor docked into the structure of the enzyme.

UR - http://www.scopus.com/inward/record.url?scp=0029060506&partnerID=8YFLogxK

U2 - 10.1016/0960-894X(95)00178-V

DO - 10.1016/0960-894X(95)00178-V

M3 - Article

AN - SCOPUS:0029060506

SN - 0960-894X

VL - 5

SP - 1125

EP - 1130

JO - BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS

JF - BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS

IS - 11

ER -

Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase

Abstract

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