Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican

TY - JOUR

T1 - Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican

AU - Favuzzi, Emilia

AU - Marques-Smith, André

AU - Deogracias, Rubén

AU - Winterflood, Christian M.

AU - Sánchez-Aguilera, Alberto

AU - Mantoan, Laura

AU - Maeso, Patricia

AU - Fernandes, Cathy

AU - Ewers, Helge

AU - Rico, Beatriz

PY - 2017/8/2

Y1 - 2017/8/2

N2 - Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.

AB - Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.

KW - Parvalbumin interneurons

KW - inhibitory circuitries

KW - perineuronal nets

KW - synapse maturation

KW - AMPA receptors

KW - Kv channels

KW - learning and memory

KW - plasticity

KW - activity-dependent

U2 - 10.1016/j.neuron.2017.06.028

DO - 10.1016/j.neuron.2017.06.028

M3 - Article

SN - 0896-6273

VL - 95

SP - 639

EP - 655

JO - Neuron

JF - Neuron

IS - 3

M1 - E10

ER -