Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican

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Abstract

Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function.
Original languageEnglish
Article numberE10
Pages (from-to)639-655
JournalNeuron
Volume95
Issue number3
Early online date14 Jul 2017
DOIs
Publication statusPublished - 2 Aug 2017

Keywords

  • Parvalbumin interneurons
  • inhibitory circuitries
  • perineuronal nets
  • synapse maturation
  • AMPA receptors
  • Kv channels
  • learning and memory
  • plasticity
  • activity-dependent

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