Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum

C R Weiss; S V K Moideen; S L Croft; P J Houghton

doi:10.1021/np000029g

Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum

C R Weiss, S V K Moideen, S L Croft, P J Houghton

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC50 values 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.

Original language	English
Pages (from-to)	1306 - 1309
Number of pages	4
Journal	Journal of Natural Products
Volume	63
Issue number	9
DOIs	https://doi.org/10.1021/np000029g
Publication status	Published - 2000

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title = "Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum",

abstract = "Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC50 values 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.",

author = "Weiss, {C R} and Moideen, {S V K} and Croft, {S L} and Houghton, {P J}",

year = "2000",

doi = "10.1021/np000029g",

language = "English",

volume = "63",

pages = "1306 -- 1309",

journal = "Journal of Natural Products",

publisher = "American Chemical Society",

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T1 - Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum

AU - Weiss, C R

AU - Moideen, S V K

AU - Croft, S L

AU - Houghton, P J

PY - 2000

Y1 - 2000

N2 - Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC50 values 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.

AB - Four naphthoquinoids from Kigelia pinnata rootbark were assessed in vitro against chloroquine-sensitive (T9-96) and -resistant (K1) Plasmodium falciparum strains and for cytotoxicity using KB cells. 2-(1-Hydroxyethyl)naphtho[2,3-b]furan-4,9-dione possessed good activity against both strains [IC50 values 627 nM (K1), 718 nM (T9-96)]. Isopinnatal, kigelinol, and isokigelinol exhibited lower activity against both strains.

UR - http://www.scopus.com/inward/record.url?scp=0033802810&partnerID=8YFLogxK

U2 - 10.1021/np000029g

DO - 10.1021/np000029g

M3 - Article

VL - 63

SP - 1306

EP - 1309

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Activity of extracts and isolated naphthoquinones from Kigelia pinnata against Plasmodium falciparum

Abstract

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