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Acupuncture for irritable bowel syndrome: 2-year follow-up of a randomised controlled trial

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Acupuncture for irritable bowel syndrome : 2-year follow-up of a randomised controlled trial. / MacPherson, Hugh; Tilbrook, Helen; Agbedjro, Deborah; Buckley, Hannah; Hewitt, Catherine; Frost, Chris.

In: Acupuncture in Medicine, Vol. 35, No. 1, 01.02.2017, p. 17-23.

Research output: Contribution to journalArticle

Harvard

MacPherson, H, Tilbrook, H, Agbedjro, D, Buckley, H, Hewitt, C & Frost, C 2017, 'Acupuncture for irritable bowel syndrome: 2-year follow-up of a randomised controlled trial', Acupuncture in Medicine, vol. 35, no. 1, pp. 17-23. https://doi.org/10.1136/acupmed-2015-010854

APA

MacPherson, H., Tilbrook, H., Agbedjro, D., Buckley, H., Hewitt, C., & Frost, C. (2017). Acupuncture for irritable bowel syndrome: 2-year follow-up of a randomised controlled trial. Acupuncture in Medicine, 35(1), 17-23. https://doi.org/10.1136/acupmed-2015-010854

Vancouver

MacPherson H, Tilbrook H, Agbedjro D, Buckley H, Hewitt C, Frost C. Acupuncture for irritable bowel syndrome: 2-year follow-up of a randomised controlled trial. Acupuncture in Medicine. 2017 Feb 1;35(1):17-23. https://doi.org/10.1136/acupmed-2015-010854

Author

MacPherson, Hugh ; Tilbrook, Helen ; Agbedjro, Deborah ; Buckley, Hannah ; Hewitt, Catherine ; Frost, Chris. / Acupuncture for irritable bowel syndrome : 2-year follow-up of a randomised controlled trial. In: Acupuncture in Medicine. 2017 ; Vol. 35, No. 1. pp. 17-23.

Bibtex Download

@article{ada52b25a7224ca580dde749edf5dd97,
title = "Acupuncture for irritable bowel syndrome: 2-year follow-up of a randomised controlled trial",
abstract = "BACKGROUND: A recent randomised controlled trial (RCT) of acupuncture as a treatment for irritable bowel syndrome (IBS) demonstrated sustained benefits over a period of 12 months post-randomisation.AIM: To extend the trial follow-up to evaluate the effects of acupuncture at 24 months post-randomisation.METHODS: Patients in primary care with ongoing IBS were recruited to a two-arm pragmatic RCT of acupuncture for IBS. Participants were randomised to the offer of up to 10 weekly sessions of acupuncture plus usual care (n=116 patients) or to continue with usual care alone (n=117). The primary outcome was the self-reported IBS symptom severity score (IBS SSS) measured at 24 months post-randomisation. Analysis was by intention-to-treat using an unstructured multivariate linear model incorporating all repeated measures.RESULTS: The overall response rate was 61%. The adjusted difference in mean IBS SSS at 24 months was -18.28 (95% CI -40.95 to 4.40) in favour of the acupuncture arm. Differences at earlier time points estimated from the multivariate model were: -27.27 (-47.69 to -6.86) at 3 months; -23.69 (-45.17 to -2.21) at 6 months; -24.09 (-45.59 to -2.59) at 9 months; and -23.06 (-44.52 to -1.59) at 12 months.CONCLUSIONS: There were no statistically significant differences between the acupuncture and usual care groups in IBS SSS at 24 months post-randomisation, and the point estimate for the mean difference was approximately 80% of the size of the statistically significant results seen at 6, 9 and 12 months.TRIAL REGISTRATION NUMBER: ISRCTN08827905.",
keywords = "ACUPUNCTURE, GASTROENTEROLOGY), PRIMARY CARE",
author = "Hugh MacPherson and Helen Tilbrook and Deborah Agbedjro and Hannah Buckley and Catherine Hewitt and Chris Frost",
year = "2017",
month = feb,
day = "1",
doi = "10.1136/acupmed-2015-010854",
language = "English",
volume = "35",
pages = "17--23",
journal = "Acupuncture in Medicine",
issn = "0964-5284",
number = "1",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Acupuncture for irritable bowel syndrome

T2 - 2-year follow-up of a randomised controlled trial

AU - MacPherson, Hugh

AU - Tilbrook, Helen

AU - Agbedjro, Deborah

AU - Buckley, Hannah

AU - Hewitt, Catherine

AU - Frost, Chris

PY - 2017/2/1

Y1 - 2017/2/1

N2 - BACKGROUND: A recent randomised controlled trial (RCT) of acupuncture as a treatment for irritable bowel syndrome (IBS) demonstrated sustained benefits over a period of 12 months post-randomisation.AIM: To extend the trial follow-up to evaluate the effects of acupuncture at 24 months post-randomisation.METHODS: Patients in primary care with ongoing IBS were recruited to a two-arm pragmatic RCT of acupuncture for IBS. Participants were randomised to the offer of up to 10 weekly sessions of acupuncture plus usual care (n=116 patients) or to continue with usual care alone (n=117). The primary outcome was the self-reported IBS symptom severity score (IBS SSS) measured at 24 months post-randomisation. Analysis was by intention-to-treat using an unstructured multivariate linear model incorporating all repeated measures.RESULTS: The overall response rate was 61%. The adjusted difference in mean IBS SSS at 24 months was -18.28 (95% CI -40.95 to 4.40) in favour of the acupuncture arm. Differences at earlier time points estimated from the multivariate model were: -27.27 (-47.69 to -6.86) at 3 months; -23.69 (-45.17 to -2.21) at 6 months; -24.09 (-45.59 to -2.59) at 9 months; and -23.06 (-44.52 to -1.59) at 12 months.CONCLUSIONS: There were no statistically significant differences between the acupuncture and usual care groups in IBS SSS at 24 months post-randomisation, and the point estimate for the mean difference was approximately 80% of the size of the statistically significant results seen at 6, 9 and 12 months.TRIAL REGISTRATION NUMBER: ISRCTN08827905.

AB - BACKGROUND: A recent randomised controlled trial (RCT) of acupuncture as a treatment for irritable bowel syndrome (IBS) demonstrated sustained benefits over a period of 12 months post-randomisation.AIM: To extend the trial follow-up to evaluate the effects of acupuncture at 24 months post-randomisation.METHODS: Patients in primary care with ongoing IBS were recruited to a two-arm pragmatic RCT of acupuncture for IBS. Participants were randomised to the offer of up to 10 weekly sessions of acupuncture plus usual care (n=116 patients) or to continue with usual care alone (n=117). The primary outcome was the self-reported IBS symptom severity score (IBS SSS) measured at 24 months post-randomisation. Analysis was by intention-to-treat using an unstructured multivariate linear model incorporating all repeated measures.RESULTS: The overall response rate was 61%. The adjusted difference in mean IBS SSS at 24 months was -18.28 (95% CI -40.95 to 4.40) in favour of the acupuncture arm. Differences at earlier time points estimated from the multivariate model were: -27.27 (-47.69 to -6.86) at 3 months; -23.69 (-45.17 to -2.21) at 6 months; -24.09 (-45.59 to -2.59) at 9 months; and -23.06 (-44.52 to -1.59) at 12 months.CONCLUSIONS: There were no statistically significant differences between the acupuncture and usual care groups in IBS SSS at 24 months post-randomisation, and the point estimate for the mean difference was approximately 80% of the size of the statistically significant results seen at 6, 9 and 12 months.TRIAL REGISTRATION NUMBER: ISRCTN08827905.

KW - ACUPUNCTURE

KW - GASTROENTEROLOGY)

KW - PRIMARY CARE

UR - http://www.scopus.com/inward/record.url?scp=85014819427&partnerID=8YFLogxK

U2 - 10.1136/acupmed-2015-010854

DO - 10.1136/acupmed-2015-010854

M3 - Article

C2 - 26980547

AN - SCOPUS:84961817071

VL - 35

SP - 17

EP - 23

JO - Acupuncture in Medicine

JF - Acupuncture in Medicine

SN - 0964-5284

IS - 1

ER -

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