Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease

TY - JOUR

T1 - Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease

AU - Quek, Lynn

AU - Sharpe, Claire

AU - Dutt, Neelanjana

AU - Height, Sue

AU - Allman, Marlene

AU - Awogbade, Moji

AU - Rees, David C.

AU - Zuckerman, Mark

AU - Thein, Swee Lay

PY - 2010/4

Y1 - 2010/4

N2 - Acute Human Parvovirus B19 (HPV B19) infection is the major cause of transient red cell aplasia (TRCA) and acute anaemia in patients with sickle cell disease (SCD). We report three cases of patients who developed nephrotic syndrome (NS) with chronic sequelae after initially presenting with HPV B19-associated TRCA. There was no correlation between evidence of HPV B19 infection and impaired renal function in our cohort of adult sickle cell patients. This is consistent with a view that although NS is potentially a rare complication of symptomatic acute HPV B19 infection, exposure to HPV B19 is not associated with an increased risk of renal disease.

AB - Acute Human Parvovirus B19 (HPV B19) infection is the major cause of transient red cell aplasia (TRCA) and acute anaemia in patients with sickle cell disease (SCD). We report three cases of patients who developed nephrotic syndrome (NS) with chronic sequelae after initially presenting with HPV B19-associated TRCA. There was no correlation between evidence of HPV B19 infection and impaired renal function in our cohort of adult sickle cell patients. This is consistent with a view that although NS is potentially a rare complication of symptomatic acute HPV B19 infection, exposure to HPV B19 is not associated with an increased risk of renal disease.

U2 - 10.1111/j.1365-2141.2009.08062.x

DO - 10.1111/j.1365-2141.2009.08062.x

M3 - Article

SN - 1365-2141

VL - 149

SP - 289

EP - 291

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 2

ER -