Acute Kidney Injury in Critically Ill Children Is Not all Acute: Lessons Over the Last 5 Years

Erin Hessey*, Nabil Melhem, Rashid Alobaidi, Emma Ulrich, Catherine Morgan, Sean M. Bagshaw, Manish D. Sinha

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    7 Citations (Scopus)


    Acute kidney injury (AKI) in the pediatric intensive care unit (PICU) is an important risk factor for increased morbidity and mortality during hospitalization. Over the past decade, accumulated data on children and young people indicates that acute episodes of kidney dysfunction can have lasting consequences on multiple organ systems and health outcomes. To date, there are no guidelines for follow-up of surviving children that may be at risk of long-term sequelae following AKI in the PICU. This narrative review aims to describe literature from the last 5 years on the risk of medium and long-term kidney and non-kidney outcomes after AKI in the PICU. More specifically, we will focus on outcomes in children and young people following AKI in the general PICU population and children undergoing cardiac surgery. These outcomes include mortality, hypertension, proteinuria, chronic kidney disease, and healthcare utilization. We also aim to highlight current gaps in knowledge in medium and long-term outcomes in this pediatric population. We suggest a framework for future research to develop evidence-based guidelines for follow-up of children surviving an episode of critical illness and AKI.

    Original languageEnglish
    Article number648587
    JournalFrontiers in Pediatrics
    Publication statusPublished - 15 Mar 2021


    • acute kideny injury
    • chronic kidney disease
    • critical care
    • healthcare utilization
    • hypertension
    • long-term follow up
    • mortality


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