Acute kidney injury in infants with congenital diaphragmatic hernia: Acute kidney injury and diaphragmatic hernia

TY - JOUR

T1 - Acute kidney injury in infants with congenital diaphragmatic hernia

T2 - Acute kidney injury and diaphragmatic hernia

AU - Arattu Thodika, Fahad

AU - Dassios, Theodore

AU - Deep, Akash

AU - Greenough, Anne

N1 - Funding Information: We thank Mrs Deirdre Gibbons for secretarial assistance. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health Funding Information: This research was supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London. Publisher Copyright: © 2022, The Author(s).

PY - 2022/7

Y1 - 2022/7

N2 - Objectives: To assess the incidence of acute kidney injury (AKI) in infants with congenital diaphragmatic hernia (CDH), including those who had fetoscopic endoluminal tracheal occlusion (FETO), and the effect of AKI on mortality and length of stay. Study design: Ten-year retrospective review of infants admitted with CDH to a tertiary perinatal centre. Result: Ninety-four infants with median gestational age of 38+1 weeks were included. Fifty-nine (62.8%) infants had AKI. Compared to infants without AKI, infants with AKI, had a similar incidence of mortality (p=0.989). In survivors, AKI was not independently associated with a longer adjusted median length of stay [23 versus 15 days (p=0.194)]. FETO was associated with an increased risk of AKI (p=0.005), but neither the mortality nor length of stay of FETO infants who had AKI was increased.Conclusion: AKI was present in the majority of infants with CDH and most common in those who had undergone FETO.

AB - Objectives: To assess the incidence of acute kidney injury (AKI) in infants with congenital diaphragmatic hernia (CDH), including those who had fetoscopic endoluminal tracheal occlusion (FETO), and the effect of AKI on mortality and length of stay. Study design: Ten-year retrospective review of infants admitted with CDH to a tertiary perinatal centre. Result: Ninety-four infants with median gestational age of 38+1 weeks were included. Fifty-nine (62.8%) infants had AKI. Compared to infants without AKI, infants with AKI, had a similar incidence of mortality (p=0.989). In survivors, AKI was not independently associated with a longer adjusted median length of stay [23 versus 15 days (p=0.194)]. FETO was associated with an increased risk of AKI (p=0.005), but neither the mortality nor length of stay of FETO infants who had AKI was increased.Conclusion: AKI was present in the majority of infants with CDH and most common in those who had undergone FETO.

UR - http://www.scopus.com/inward/record.url?scp=85127635963&partnerID=8YFLogxK

U2 - 10.1038/s41372-022-01378-6

DO - 10.1038/s41372-022-01378-6

M3 - Article

SN - 0743-8346

VL - 42

SP - 925

EP - 929

JO - Journal of Perinatology

JF - Journal of Perinatology

IS - 7

ER -