Acute regulation of PDK1 by a complex interplay of molecular switches

Veronique Calleja; Michel Laguerre; Gloria  de las Heras-Martinez; Peter Parker; Jose Requejo-Isidro; Banafshe Larijani

doi:10.1042/BST20140222

Acute regulation of PDK1 by a complex interplay of molecular switches

Veronique Calleja, Michel Laguerre, Gloria de las Heras-Martinez, Peter Parker, Jose Requejo-Isidro, Banafshe Larijani

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26 Citations (Scopus)

Abstract

Phosphoinositide-dependent kinase 1 (PDK1) is the master regulator of at least 23 other AGC kinases whose downstream signalling has often been implicated in various diseases and in particular in cancer. Therefore there has been great interest in determining how PDK1 is controlled and how it regulates its substrates spatially and temporally. The understanding of these mechanisms could offer new possibilities for therapeutic intervention. Over the years, a more comprehensive view of the mechanisms involved in the regulation of PDK1 has emerged and these comprise serine/threonine as well as tyrosine phosphorylation, subcellular localization, regulator binding and conformation status. In the present review, we discuss how various molecular mechanisms are together responsible for the conformational regulation behind the activation of PDK1 in cells.

Original language	English
Pages (from-to)	1435-1440
Number of pages	6
Journal	Biochemical Society Transactions
Volume	42
Issue number	5
DOIs	https://doi.org/10.1042/BST20140222
Publication status	Published - Oct 2014

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AU - Calleja, Veronique

AU - Laguerre, Michel

AU - de las Heras-Martinez, Gloria

AU - Parker, Peter

AU - Requejo-Isidro, Jose

AU - Larijani, Banafshe

PY - 2014/10

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AB - Phosphoinositide-dependent kinase 1 (PDK1) is the master regulator of at least 23 other AGC kinases whose downstream signalling has often been implicated in various diseases and in particular in cancer. Therefore there has been great interest in determining how PDK1 is controlled and how it regulates its substrates spatially and temporally. The understanding of these mechanisms could offer new possibilities for therapeutic intervention. Over the years, a more comprehensive view of the mechanisms involved in the regulation of PDK1 has emerged and these comprise serine/threonine as well as tyrosine phosphorylation, subcellular localization, regulator binding and conformation status. In the present review, we discuss how various molecular mechanisms are together responsible for the conformational regulation behind the activation of PDK1 in cells.

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M3 - Article

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JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

IS - 5

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Acute regulation of PDK1 by a complex interplay of molecular switches

Abstract

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