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Adaptive Behaviour and Cognitive Skills: Stability and Change from 7 Months to 7 Years in Siblings at High Familial Risk of Autism Spectrum Disorder

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the BASIS TEAM, Erica Salomone, Elizabeth Shephard, Bosiljka Milosavljevic, Mark H. Johnson, Tony Charman, Simon Baron-Cohen, Rachael Bedford, Patrick Bolton, Susie Chandler, Mayada Elsabbagh, Janice Fernandes, Holly Garwood, Teodora Gliga, Kristelle Hudry, Emily J.H. Jones, Greg Pasco, Andrew Pickles, Leslie Tucker, Agnes Volein

Original languageEnglish
Pages (from-to)2901–2911
Number of pages11
JournalJournal of Autism and Developmental Disorders
Issue number9
Early online date3 Apr 2018
Publication statusPublished - Sep 2018


King's Authors


Cognitive and adaptive behaviour abilities early in life provide important clinical prognostic information. We examined stability of such skills in children at high familial risk for ASD who either met diagnostic criteria for ASD at age 7 years (HR-ASD, n = 15) or did not (HR-non-ASD, n = 24) and low-risk control children (LR, n = 37), prospectively studied from infancy. For both HR groups, cognitive skills were consistently lower across time than those of LR children. HR-ASD children showed increasing difficulties in adaptive behaviour over time compared to LR children, while the HR-non-ASD children showed no such difficulties. This pattern of change may inform our understanding of developmental profiles of HR siblings beyond core ASD symptoms.

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