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Adaptive from innate: Human IFN-γ+ CD4+ T cells can arise directly from CXCL8-producing recent thymic emigrants in babies and adults

Research output: Contribution to journalArticle

Abhishek Das, Kevin Rouault-Pierre, Shraddha Kamdar, Iria Gomez-Tourino, Kristie Wood, Ian Donaldson, Charles Mein, Dominique Bonnet, Adrian C. Hayday, Deena L. Gibbons

Original languageEnglish
Pages (from-to)1696-1705
Number of pages10
JournalJournal of Immunology
Issue number5
Early online date21 Aug 2017
Accepted/In press27 Jun 2017
E-pub ahead of print21 Aug 2017
Published1 Sep 2017


King's Authors


We recently demonstrated that the major effector function of neonatal CD4+ T cells is to produce CXCL8, a prototypic cytokine of innate immune cells. In this article, we show that CXCL8 expression, prior to proliferation, is common in newly arising T cells (so-called “recent thymic emigrants”) in adults, as well as in babies. This effector potential is acquired in the human thymus, prior to TCR signaling, but rather than describing end-stage differentiation, such cells, whether isolated from neonates or adults, can further differentiate into IFN-γ–producing CD4+ T cells. Thus, the temporal transition of host defense from innate to adaptive immunity is unexpectedly mirrored at the cellular level by the capacity of human innate-like CXCL8-producing CD4+ T cells to transition directly into Th1 cells.

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