Adaptive immune responses to Candida albicans infection

Jonathan P. Richardson, David L. Moyes*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

133 Citations (Scopus)
202 Downloads (Pure)

Abstract

Fungal infections are becoming increasingly prevalent in the human population and contribute to morbidity and mortality in healthy and immunocompromised individuals respectively. Candida albicans is the most commonly encountered fungal pathogen of humans, and is frequently found on the mucosal surfaces of the body. Host defense against C. albicans is dependent upon a finely tuned implementation of innate and adaptive immune responses, enabling the host to neutralise the invading fungus. Central to this protection are the adaptive Th1 and Th17 cellular responses, which are considered paramount to successful immune defense against C. albicans infections, and enable tissue homeostasis to be maintained in the presence of colonising fungi. This review will highlight the recent advances in our understanding of adaptive immunity to Candida albicans infections.

Original languageEnglish
Pages (from-to)327-337
Number of pages11
JournalVirulence
Volume6
Issue number4
DOIs
Publication statusPublished - 21 Jan 2015

Keywords

  • Adaptive immunity
  • Candida albicans
  • Fungal infection

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