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Additional First-Trimester Ultrasound Markers

Research output: Contribution to journalArticle

J. Sonek, K. Nicolaides

Original languageEnglish
Pages (from-to)573 - +
Number of pages20
JournalClinics in Laboratory Medicine
Issue number3
Publication statusPublished - Sep 2010

King's Authors


The first trimester (11-13 +6 weeks) ultrasound examination is useful for several reasons: determination of an accurate date of confinement, diagnostic purposes, and screening for fetal defects. Nuchal translucency measurement combined with maternal serum markers (free b-human chorionic gonadotropin and pregnancy-associated plasma protein A) is the mainstay of first-trimester screening for chromosomal defects. However, over the past decade additional ultrasound markers have been developed that improve the performance of this type of screening. The novel markers include evaluation of the nasal bone, fronto-maxillary angle measurement, and Doppler evaluations of the blood flow across the tricuspid valve and in the ductus venosus.

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