Addressing unmet needs in understanding asthma mechanisms

Michael R. Edwards; Sejal Saglani; Jurgen Schwarze; Chrysanthi Skevaki; Jaclyn A. Smith; Ben Ainsworth; Mark Almond; Evangelos Andreakos; Maria G. Belvisi; Kian Fan Chung; William Cookson; Paul Cullinan; Catherine Hawrylowicz; Marek Lommatzsch; David Jackson; Rene Lutter; Benjamin Marsland; Miriam Moffatt; Mike Thomas; J. Christian Virchow; Georgina Xanthou; Jessica Edwards; Samantha Walker; Sebastian L. Johnston; Ian Adcock; Cezmi Akdis; Elisabeth Bel; Jean Bousquet; Anneke Ten Brinke; Guy Brusselle; Sven Erik Dáhlen; Ratko Djukanovic; Mina Gaga; Luis Garcia-Marcos; Pieter Hiemstra; Enrico Heffler; Stephen Holgate; Maciek Kupczyk; Clare Lloyd; Jane Lucas; Antoine Magnan; Thomas Martin; David Myles; Clive Page; Susanna Palkonen; Nikos Papadopoulos; Alberto Papi; Pippa Powell; John Riley; Ian Sayers; Antonio Spanevello; Peter Sterk; Paraskevi Xepapadaki; Craig Wheelock

doi:10.1183/13993003.02448-2016

Addressing unmet needs in understanding asthma mechanisms

Michael R. Edwards, Sejal Saglani, Jurgen Schwarze, Chrysanthi Skevaki, Jaclyn A. Smith, Ben Ainsworth, Mark Almond, Evangelos Andreakos, Maria G. Belvisi, Kian Fan Chung, William Cookson, Paul Cullinan, Catherine Hawrylowicz, Marek Lommatzsch, David Jackson, Rene Lutter, Benjamin Marsland, Miriam Moffatt, Mike Thomas, J. Christian VirchowGeorgina Xanthou, Jessica Edwards, Samantha Walker, Sebastian L. Johnston^*, Ian Adcock, Cezmi Akdis, Elisabeth Bel, Jean Bousquet, Anneke Ten Brinke, Guy Brusselle, Sven Erik Dáhlen, Ratko Djukanovic, Mina Gaga, Luis Garcia-Marcos, Pieter Hiemstra, Enrico Heffler, Stephen Holgate, Maciek Kupczyk, Clare Lloyd, Jane Lucas, Antoine Magnan, Thomas Martin, David Myles, Clive Page, Susanna Palkonen, Nikos Papadopoulos, Alberto Papi, Pippa Powell, John Riley, Ian Sayers, Antonio Spanevello, Peter Sterk, Paraskevi Xepapadaki, Craig Wheelock

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

51 Citations (Scopus)

Abstract

Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.

Original language	English
Article number	1602448
Journal	European Respiratory Journal
Volume	49
Issue number	5
Early online date	1 May 2017
DOIs	https://doi.org/10.1183/13993003.02448-2016
Publication status	Published - May 2017

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Edwards, M. R., Saglani, S., Schwarze, J., Skevaki, C., Smith, J. A., Ainsworth, B., Almond, M., Andreakos, E., Belvisi, M. G., Chung, K. F., Cookson, W., Cullinan, P., Hawrylowicz, C., Lommatzsch, M., Jackson, D., Lutter, R., Marsland, B., Moffatt, M., Thomas, M., ... Wheelock, C. (2017). Addressing unmet needs in understanding asthma mechanisms. European Respiratory Journal, 49(5), Article 1602448. https://doi.org/10.1183/13993003.02448-2016

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title = "Addressing unmet needs in understanding asthma mechanisms",

abstract = "Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.",

author = "Edwards, {Michael R.} and Sejal Saglani and Jurgen Schwarze and Chrysanthi Skevaki and Smith, {Jaclyn A.} and Ben Ainsworth and Mark Almond and Evangelos Andreakos and Belvisi, {Maria G.} and Chung, {Kian Fan} and William Cookson and Paul Cullinan and Catherine Hawrylowicz and Marek Lommatzsch and David Jackson and Rene Lutter and Benjamin Marsland and Miriam Moffatt and Mike Thomas and Virchow, {J. Christian} and Georgina Xanthou and Jessica Edwards and Samantha Walker and Johnston, {Sebastian L.} and Ian Adcock and Cezmi Akdis and Elisabeth Bel and Jean Bousquet and {Ten Brinke}, Anneke and Guy Brusselle and D{\'a}hlen, {Sven Erik} and Ratko Djukanovic and Mina Gaga and Luis Garcia-Marcos and Pieter Hiemstra and Enrico Heffler and Stephen Holgate and Maciek Kupczyk and Clare Lloyd and Jane Lucas and Antoine Magnan and Thomas Martin and David Myles and Clive Page and Susanna Palkonen and Nikos Papadopoulos and Alberto Papi and Pippa Powell and John Riley and Ian Sayers and Antonio Spanevello and Peter Sterk and Paraskevi Xepapadaki and Craig Wheelock",

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Edwards, MR, Saglani, S, Schwarze, J, Skevaki, C, Smith, JA, Ainsworth, B, Almond, M, Andreakos, E, Belvisi, MG, Chung, KF, Cookson, W, Cullinan, P, Hawrylowicz, C, Lommatzsch, M, Jackson, D, Lutter, R, Marsland, B, Moffatt, M, Thomas, M, Virchow, JC, Xanthou, G, Edwards, J, Walker, S, Johnston, SL, Adcock, I, Akdis, C, Bel, E, Bousquet, J, Ten Brinke, A, Brusselle, G, Dáhlen, SE, Djukanovic, R, Gaga, M, Garcia-Marcos, L, Hiemstra, P, Heffler, E, Holgate, S, Kupczyk, M, Lloyd, C, Lucas, J, Magnan, A, Martin, T, Myles, D, Page, C, Palkonen, S, Papadopoulos, N, Papi, A, Powell, P, Riley, J, Sayers, I, Spanevello, A, Sterk, P, Xepapadaki, P & Wheelock, C 2017, 'Addressing unmet needs in understanding asthma mechanisms', European Respiratory Journal, vol. 49, no. 5, 1602448. https://doi.org/10.1183/13993003.02448-2016

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T1 - Addressing unmet needs in understanding asthma mechanisms

AU - Edwards, Michael R.

AU - Saglani, Sejal

AU - Schwarze, Jurgen

AU - Skevaki, Chrysanthi

AU - Smith, Jaclyn A.

AU - Ainsworth, Ben

AU - Almond, Mark

AU - Andreakos, Evangelos

AU - Belvisi, Maria G.

AU - Chung, Kian Fan

AU - Cookson, William

AU - Cullinan, Paul

AU - Hawrylowicz, Catherine

AU - Lommatzsch, Marek

AU - Jackson, David

AU - Lutter, Rene

AU - Marsland, Benjamin

AU - Moffatt, Miriam

AU - Thomas, Mike

AU - Virchow, J. Christian

AU - Xanthou, Georgina

AU - Edwards, Jessica

AU - Walker, Samantha

AU - Johnston, Sebastian L.

AU - Adcock, Ian

AU - Akdis, Cezmi

AU - Bel, Elisabeth

AU - Bousquet, Jean

AU - Ten Brinke, Anneke

AU - Brusselle, Guy

AU - Dáhlen, Sven Erik

AU - Djukanovic, Ratko

AU - Gaga, Mina

AU - Garcia-Marcos, Luis

AU - Hiemstra, Pieter

AU - Heffler, Enrico

AU - Holgate, Stephen

AU - Kupczyk, Maciek

AU - Lloyd, Clare

AU - Lucas, Jane

AU - Magnan, Antoine

AU - Martin, Thomas

AU - Myles, David

AU - Page, Clive

AU - Palkonen, Susanna

AU - Papadopoulos, Nikos

AU - Papi, Alberto

AU - Powell, Pippa

AU - Riley, John

AU - Sayers, Ian

AU - Spanevello, Antonio

AU - Sterk, Peter

AU - Xepapadaki, Paraskevi

AU - Wheelock, Craig

PY - 2017/5

Y1 - 2017/5

N2 - Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.

AB - Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.

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U2 - 10.1183/13993003.02448-2016

DO - 10.1183/13993003.02448-2016

M3 - Review article

AN - SCOPUS:85019122058

SN - 0903-1936

VL - 49

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 5

M1 - 1602448

ER -

Addressing unmet needs in understanding asthma mechanisms

Abstract

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