Adeno-associated virus biology

Matthew D Weitzman, R Michael Linden

Research output: Chapter in Book/Report/Conference proceedingChapter

91 Citations (Scopus)

Abstract

Adeno-associated virus (AAV) was first discovered as a contaminant of adenovirus stocks in the 1960s. The development of recombinant AAV vectors (rAAV) was facilitated by early studies that generated infectious molecular clones, determined the sequence of the genome, and defined the genetic elements of the virus. The refinement of methods and protocols for the production and application of rAAV vectors has come from years of studies that explored the basic biology of this virus and its interaction with host cells. Interest in improving vector performance has in turn driven studies that have provided tremendous insights into the basic biology of the AAV lifecycle. In this chapter, we review the background on AAV biology and its exploitation for vectors and gene delivery.
Original languageEnglish
Title of host publicationAdeno-Associated Virus
Subtitle of host publicationMethods and Protocols
Pages1-23
Number of pages23
Volume807
ISBN (Electronic)978-1-61779-370-7
DOIs
Publication statusPublished - 2011

Publication series

NameMethods in Molecular Biology
PublisherHumana Press
Volume807
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

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