Adhesion G-protein coupled receptors: Implications for metabolic function

Oladapo E Olaniru; Shanta J Persaud

doi:10.1016/j.pharmthera.2019.02.012

Adhesion G-protein coupled receptors: Implications for metabolic function

Oladapo E Olaniru, Shanta J Persaud

Diabetes

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

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Abstract

Adhesion G-protein coupled receptors (aGPCRs) are emerging as important actors in energy homeostasis. Recent biochemical and functional studies using transgenic mice indicate that aGPCRs play important roles in endocrine and metabolic functions including β-cell differentiation, insulin secretion, adipogenesis and whole body fuel homeostasis. Most aGPCRs are orphans, for which endogenous ligands have not yet been identified, and many of the endogenous ligands of the already de-orphanised aGPCRs are components of the extracellular matrix (ECM). In this review we focus on aGPCR expression in metabolically active tissues, their activation by ECM proteins, and current knowledge of their potential roles in islet development, insulin secretion, adipogenesis and muscle function.

Original language	English
Pages (from-to)	123-134
Number of pages	12
Journal	Pharmacology and Therapeutics
Volume	198
Early online date	27 Feb 2019
DOIs	https://doi.org/10.1016/j.pharmthera.2019.02.012
Publication status	Published - 1 Jun 2019

Keywords

Adhesion GPCRs
Adipose
Diabetes
Extracellular matrix proteins
Islets
Liver
Muscle
Pancreas

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pharmthera.2019.02.012

AdhesionG-proteincoupledreceptors_OLANIRU_Publishedonline27February2019_GREEN AAM (CC BY)Accepted author manuscript, 4.17 MBLicence: CC BY-NC-ND

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AU - Persaud, Shanta J

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KW - Adhesion GPCRs

KW - Adipose

KW - Diabetes

KW - Extracellular matrix proteins

KW - Islets

KW - Liver

KW - Muscle

KW - Pancreas

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Adhesion G-protein coupled receptors: Implications for metabolic function

Abstract

Keywords

UN SDGs

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