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Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures

Research output: Contribution to journalArticlepeer-review

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Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures. / Salzlechner, Christoph; Haghighi, Tabasom; Huebscher, Isabella et al.

In: Advanced Healthcare Materials, Vol. 9, No. 4, e1901134, 19.02.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Salzlechner, C, Haghighi, T, Huebscher, I, Walther, AR, Schell, S, Gardner, A, Undt, G, da Silva, RMP, Dreiss, CA, Fan, K & Gentleman, E 2020, 'Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures', Advanced Healthcare Materials, vol. 9, no. 4, e1901134. https://doi.org/10.1002/adhm.201901134

APA

Salzlechner, C., Haghighi, T., Huebscher, I., Walther, A. R., Schell, S., Gardner, A., Undt, G., da Silva, R. M. P., Dreiss, C. A., Fan, K., & Gentleman, E. (2020). Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures. Advanced Healthcare Materials, 9(4), [e1901134]. https://doi.org/10.1002/adhm.201901134

Vancouver

Salzlechner C, Haghighi T, Huebscher I, Walther AR, Schell S, Gardner A et al. Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures. Advanced Healthcare Materials. 2020 Feb 19;9(4). e1901134. https://doi.org/10.1002/adhm.201901134

Author

Salzlechner, Christoph ; Haghighi, Tabasom ; Huebscher, Isabella et al. / Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures. In: Advanced Healthcare Materials. 2020 ; Vol. 9, No. 4.

Bibtex Download

@article{3f828b3c19ad467ea7b08abcd330a9a0,
title = "Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures",
abstract = "Minimally invasive surgical procedures aiming to repair damaged maxillofacial tissues are hampered by its small, complex structures and difficult surgical access. Indeed, while arthroscopic procedures that deliver regenerative materials and/or cells are common in articulating joints such as the knee, there are currently no treatments that surgically place cells, regenerative factors or materials into maxillofacial tissues to foster bone, cartilage or muscle repair. Here, hyaluronic acid (HA)-based hydrogels are developed, which are suitable for use in minimally invasive procedures, that can adhere to the surrounding tissue, and deliver cells and potentially drugs. By modifying HA with both methacrylate (MA) and 3,4-dihydroxyphenylalanine (Dopa) groups using a completely aqueous synthesis route, it is shown that MA-HA-Dopa hydrogels can be applied under aqueous conditions, gel quickly using a standard surgical light, and adhere to tissue. Moreover, upon oxidation of the Dopa, human marrow stromal cells attach to hydrogels and survive when encapsulated within them. These observations show that when incorporated into HA-based hydrogels, Dopa moieties can foster cell and tissue interactions, ensuring surgical placement and potentially enabling delivery/recruitment of regenerative cells. The findings suggest that MA-HA-Dopa hydrogels may find use in minimally invasive procedures to foster maxillofacial tissue repair.",
keywords = "adhesivity, biomaterials, hydrogels, minimally invasive surgery, tissue engineering",
author = "Christoph Salzlechner and Tabasom Haghighi and Isabella Huebscher and Walther, {Anders Runge} and Sophie Schell and Alexander Gardner and Gerhard Undt and {da Silva}, {Ricardo M.P.} and Dreiss, {Cecile A.} and Kathleen Fan and Eileen Gentleman",
year = "2020",
month = feb,
day = "19",
doi = "10.1002/adhm.201901134",
language = "English",
volume = "9",
journal = "Advanced Healthcare Materials",
issn = "2192-2640",
publisher = "John Wiley and Sons Ltd",
number = "4",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures

AU - Salzlechner, Christoph

AU - Haghighi, Tabasom

AU - Huebscher, Isabella

AU - Walther, Anders Runge

AU - Schell, Sophie

AU - Gardner, Alexander

AU - Undt, Gerhard

AU - da Silva, Ricardo M.P.

AU - Dreiss, Cecile A.

AU - Fan, Kathleen

AU - Gentleman, Eileen

PY - 2020/2/19

Y1 - 2020/2/19

N2 - Minimally invasive surgical procedures aiming to repair damaged maxillofacial tissues are hampered by its small, complex structures and difficult surgical access. Indeed, while arthroscopic procedures that deliver regenerative materials and/or cells are common in articulating joints such as the knee, there are currently no treatments that surgically place cells, regenerative factors or materials into maxillofacial tissues to foster bone, cartilage or muscle repair. Here, hyaluronic acid (HA)-based hydrogels are developed, which are suitable for use in minimally invasive procedures, that can adhere to the surrounding tissue, and deliver cells and potentially drugs. By modifying HA with both methacrylate (MA) and 3,4-dihydroxyphenylalanine (Dopa) groups using a completely aqueous synthesis route, it is shown that MA-HA-Dopa hydrogels can be applied under aqueous conditions, gel quickly using a standard surgical light, and adhere to tissue. Moreover, upon oxidation of the Dopa, human marrow stromal cells attach to hydrogels and survive when encapsulated within them. These observations show that when incorporated into HA-based hydrogels, Dopa moieties can foster cell and tissue interactions, ensuring surgical placement and potentially enabling delivery/recruitment of regenerative cells. The findings suggest that MA-HA-Dopa hydrogels may find use in minimally invasive procedures to foster maxillofacial tissue repair.

AB - Minimally invasive surgical procedures aiming to repair damaged maxillofacial tissues are hampered by its small, complex structures and difficult surgical access. Indeed, while arthroscopic procedures that deliver regenerative materials and/or cells are common in articulating joints such as the knee, there are currently no treatments that surgically place cells, regenerative factors or materials into maxillofacial tissues to foster bone, cartilage or muscle repair. Here, hyaluronic acid (HA)-based hydrogels are developed, which are suitable for use in minimally invasive procedures, that can adhere to the surrounding tissue, and deliver cells and potentially drugs. By modifying HA with both methacrylate (MA) and 3,4-dihydroxyphenylalanine (Dopa) groups using a completely aqueous synthesis route, it is shown that MA-HA-Dopa hydrogels can be applied under aqueous conditions, gel quickly using a standard surgical light, and adhere to tissue. Moreover, upon oxidation of the Dopa, human marrow stromal cells attach to hydrogels and survive when encapsulated within them. These observations show that when incorporated into HA-based hydrogels, Dopa moieties can foster cell and tissue interactions, ensuring surgical placement and potentially enabling delivery/recruitment of regenerative cells. The findings suggest that MA-HA-Dopa hydrogels may find use in minimally invasive procedures to foster maxillofacial tissue repair.

KW - adhesivity

KW - biomaterials

KW - hydrogels

KW - minimally invasive surgery

KW - tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85077869056&partnerID=8YFLogxK

U2 - 10.1002/adhm.201901134

DO - 10.1002/adhm.201901134

M3 - Article

VL - 9

JO - Advanced Healthcare Materials

JF - Advanced Healthcare Materials

SN - 2192-2640

IS - 4

M1 - e1901134

ER -

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