TY - JOUR
T1 - Adolescent depression and resting-state fMRI brain networks
T2 - a scoping review of longitudinal studies
AU - Macêdo, Marcos Antônio
AU - Sato, João Ricardo
AU - Bressan, Rodrigo A.
AU - Pan, Pedro Mario
N1 - Funding Information:
RAB has received research grants from Janssen Cilag, Novartis, and Roche; has been a forum consultant for Janssen, Novartis, and Roche; and has participated in speaker bureaus for Ache, Janssen, Lundbeck, and Novartis. PMP has received payment or honoraria for lectures and presentations in educational events for Sandoz, Daiichi Sankyo, Eurofarma, Abbott, Libbs, Instituto Israelita de Pesquisa e Ensino Albert Einstein, and Instituto D’Or de Pesquisa e Ensino. The other authors report no conflicts of interest.
Funding Information:
This study was partially supported by Instituto Nacional de Psiquiatria do Desenvolvimento (INPD) with grants from the Brazilian government agencies Fundac¸ão de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (#Fapesp 2014/50917-0) and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) (#CNPq 465550/2014-2). JRS is supported by FAPESP (grants #2018/21934-5 and #2018/04654-9.
Publisher Copyright:
© 2022, Associacao Brasileira de Psiquiatria. All rights reserved.
PY - 2022
Y1 - 2022
N2 - The neurobiological factors associated with the emergence of major depressive disorder (MDD) in adolescence are still unclear. Previous cross-sectional studies have documented aberrant connectivity in resting-state functional magnetic resonance imaging (rs-fMRI) networks. However, whether these findings precede MDD onset has not been established. This scoping review mapped key methodological aspects and main findings of longitudinal rs-fMRI studies of MDD in adolescence. Three sets of neuroimaging methods to analyze rs-fMRI data were identified: seed-based analysis, independent component analysis, and network-based approaches. Main findings involved aberrant connectivity within and between the default mode network (DMN), the cognitive control network (CCN), and the salience network (SN). Accordingly, we utilized Menon’s (2011) triple-network model for neuropsychiatric disorders to summarize key results. Adolescent MDD was associated with hyperconnectivity within the SN and between DMN and SN, as well as hypoconnectivity within the CCN. These findings suggested that dysfunctional connectivity among the three main large-scale brain networks preceded MDD onset. However, there was high heterogeneity in neuroimaging methods and sampling procedures, which may limit comparisons between studies. Future studies should consider some level of harmonization for clinical instruments and neuroimaging methods.
AB - The neurobiological factors associated with the emergence of major depressive disorder (MDD) in adolescence are still unclear. Previous cross-sectional studies have documented aberrant connectivity in resting-state functional magnetic resonance imaging (rs-fMRI) networks. However, whether these findings precede MDD onset has not been established. This scoping review mapped key methodological aspects and main findings of longitudinal rs-fMRI studies of MDD in adolescence. Three sets of neuroimaging methods to analyze rs-fMRI data were identified: seed-based analysis, independent component analysis, and network-based approaches. Main findings involved aberrant connectivity within and between the default mode network (DMN), the cognitive control network (CCN), and the salience network (SN). Accordingly, we utilized Menon’s (2011) triple-network model for neuropsychiatric disorders to summarize key results. Adolescent MDD was associated with hyperconnectivity within the SN and between DMN and SN, as well as hypoconnectivity within the CCN. These findings suggested that dysfunctional connectivity among the three main large-scale brain networks preceded MDD onset. However, there was high heterogeneity in neuroimaging methods and sampling procedures, which may limit comparisons between studies. Future studies should consider some level of harmonization for clinical instruments and neuroimaging methods.
KW - adolescent psychiatry
KW - functional neuroimaging
KW - longitudinal studies
KW - Magnetic resonance imaging
KW - major depressive disorder
UR - http://www.scopus.com/inward/record.url?scp=85136280370&partnerID=8YFLogxK
U2 - 10.47626/1516-4446-2021-2032
DO - 10.47626/1516-4446-2021-2032
M3 - Article
C2 - 35896034
AN - SCOPUS:85136280370
SN - 1516-4446
VL - 44
SP - 420
EP - 433
JO - Brazilian Journal of Psychiatry
JF - Brazilian Journal of Psychiatry
IS - 4
ER -
