Abstract
Adolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist in psychopathology, which might be mirrored in underlying sex differences in structural development. However, previous studies showed inconsistencies in subcortical trajectories and potential sex differences. Therefore, we aimed to investigate the subcortical structural trajectories and their sex differences across adolescence using for the first time a single cohort design, the same quality control procedure, software, and a general additive mixed modeling approach. We investigated two large European sites from ages 14 to 24 with 503 participants and 1408 total scans from France and Germany as part of the IMAGEN project including four waves of data acquisition. We found significantly larger volumes in males versus females in both sites and across all seven subcortical regions. Sex differences in age-related trajectories were observed across all regions in both sites. Our findings provide further evidence of sex differences in longitudinal adolescent brain development of subcortical regions and thus might eventually support the relationship of underlying brain development and different adolescent psychopathology in boys and girls.
| Original language | English |
|---|---|
| Article number | e26574 |
| Pages (from-to) | e26574 |
| Journal | Human Brain Mapping |
| Volume | 45 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 24 Feb 2024 |
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- 10.1002/hbm.26574Licence: CC BY
- Human Brain Mapping - 2024 - Backhausen - Adolescent to young adult longitudinal development of subcortical volumes in two
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,provided the original work is properly cited.© 2024 The Authors.Human Brain Mapping published by Wiley Periodicals LLC.
Final published version, 5.48 MBLicence: CC BY
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In: Human Brain Mapping, Vol. 45, No. 3, e26574, 24.02.2024, p. e26574.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Adolescent to young adult longitudinal development of subcortical volumes in two European sites with four waves
AU - IMAGEN Consortium
AU - Backhausen, Lea L
AU - Fröhner, Juliane H
AU - Lemaître, Hervé
AU - Artiges, Eric
AU - Martinot, Marie-Laure Palillère
AU - Herting, Megan M
AU - Sticca, Fabio
AU - Banaschewski, Tobias
AU - Barker, Gareth J
AU - Bokde, Arun L W
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Grigis, Antoine
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Brühl, Rüdiger
AU - Nees, Frauke
AU - Papadopoulos-Orfanos, Dimitri
AU - Poustka, Luise
AU - Hohmann, Sarah
AU - Robinson, Lauren
AU - Walter, Henrik
AU - Winterer, Jeanne
AU - Whelan, Robert
AU - Schumann, Gunter
AU - Martinot, Jean-Luc
AU - Smolka, Michael N
AU - Vetter, Nora C
N1 - Funding Information: This work received support from the following sources: the European Union-funded FP6 Integrated Project IMAGEN (Reinforcement-related behaviour in normal brain function and psychopathology) (LSHM-CT-2007-037286), the Horizon 2020 funded ERC Advanced Grant “STRATIFY” (Brain network based stratification of reinforcement-related disorders) (695313), Human Brain Project (HBP SGA 2, 785907, and HBP SGA 3, 945539), the Medical Research Council Grant “c-VEDA” (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1), the National Institute of Health (NIH) (R01DA049238, A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers), the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, the Bundesministerium für Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; Forschungsnetz AERIAL 01EE1406A, 01EE1406B; Forschungsnetz IMAC-Mind 01GL1745B), the Deutsche Forschungsgemeinschaft (DFG project numbers 186318919 (FOR 1617), 178833530 (SFB 940), 402170461 (TRR 265), 290210763 (VE 892/2-1), NE 1383/14-1); Faculty of Medicine at the Technische Universität Dresden, MeDDrive Grant; the Medical Research Foundation and Medical Research Council (grants MR/R00465X/1 and MR/S020306/1), the National Institutes of Health (NIH) funded ENIGMA (grants 5U54EB020403-05 and 1R56AG058854-01). Further support was provided by grants from: the ANR (ANR-12-SAMA-0004, AAPG2019—GeBra), the Eranet Neuron (AF12-NEUR0008-01—WM2NA; and ANR-18-NEUR00002-01—ADORe), the Fondation de France (00081242, 2012-00033703), the Fondation pour la Recherche Médicale (FRM; DPA20140629802; DPP20151033945), the Mission Interministérielle de Lutte-contre-les-Drogues-et-les-Conduites-Addictives (MILDECA), the Assistance-Publique-Hôpitaux-de-Paris and INSERM (interface grant), Paris Sud University IDEX 2012, the Fondation de l'Avenir (grant AP-RM-17-013), the Fédération pour la Recherche sur le Cerveau (FRC Neurodon 2015); the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), U.S.A. (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772-01A1), and by NIH Consortium grant U54 EB020403, supported by a cross-NIH alliance that funds Big Data to Knowledge Centres of Excellence. Resources of The Center for Information Services and High Performance Computing (ZIH) at TU Dresden were used for fast data processing. We thank Jonas Granzow for help with data processing, quality control, and some figures and tables. We further wish to thank Annabell Baake, Leonie Epple, Carolin Fritzsche, and Isabell Theilig for assistance with data management and quality control. Lastly, we thank all participants and their families for their enduring commitment to the study over the years. Open Access funding enabled and organized by Projekt DEAL. Funding Information: This work received support from the following sources: the European Union‐funded FP6 Integrated Project IMAGEN (Reinforcement‐related behaviour in normal brain function and psychopathology) (LSHM‐CT‐2007‐037286), the Horizon 2020 funded ERC Advanced Grant “STRATIFY” (Brain network based stratification of reinforcement‐related disorders) (695313), Human Brain Project (HBP SGA 2, 785907, and HBP SGA 3, 945539), the Medical Research Council Grant “c‐VEDA” (Consortium on Vulnerability to Externalizing Disorders and Addictions) (MR/N000390/1), the National Institute of Health (NIH) (R01DA049238, A decentralized macro and micro gene‐by‐environment interaction analysis of substance use behavior and its brain biomarkers), the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London, the Bundesministerium für Bildung und Forschung (BMBF grants 01GS08152; 01EV0711; Forschungsnetz AERIAL 01EE1406A, 01EE1406B; Forschungsnetz IMAC‐Mind 01GL1745B), the Deutsche Forschungsgemeinschaft (DFG project numbers 186318919 (FOR 1617), 178833530 (SFB 940), 402170461 (TRR 265), 290210763 (VE 892/2‐1), NE 1383/14‐1); Faculty of Medicine at the Technische Universität Dresden, MeDDrive Grant; the Medical Research Foundation and Medical Research Council (grants MR/R00465X/1 and MR/S020306/1), the National Institutes of Health (NIH) funded ENIGMA (grants 5U54EB020403‐05 and 1R56AG058854‐01). Further support was provided by grants from: the ANR (ANR‐12‐SAMA‐0004, AAPG2019—GeBra), the Eranet Neuron (AF12‐NEUR0008‐01—WM2NA; and ANR‐18‐NEUR00002‐01—ADORe), the Fondation de France (00081242, 2012‐00033703), the Fondation pour la Recherche Médicale (FRM; DPA20140629802; DPP20151033945), the Mission Interministérielle de Lutte‐contre‐les‐Drogues‐et‐les‐Conduites‐Addictives (MILDECA), the Assistance‐Publique‐Hôpitaux‐de‐Paris and INSERM (interface grant), Paris Sud University IDEX 2012, the Fondation de l'Avenir (grant AP‐RM‐17‐013), the Fédération pour la Recherche sur le Cerveau (FRC Neurodon 2015); the National Institutes of Health, Science Foundation Ireland (16/ERCD/3797), U.S.A. (Axon, Testosterone and Mental Health during Adolescence; RO1 MH085772‐01A1), and by NIH Consortium grant U54 EB020403, supported by a cross‐NIH alliance that funds Big Data to Knowledge Centres of Excellence. Resources of The Center for Information Services and High Performance Computing (ZIH) at TU Dresden were used for fast data processing. We thank Jonas Granzow for help with data processing, quality control, and some figures and tables. We further wish to thank Annabell Baake, Leonie Epple, Carolin Fritzsche, and Isabell Theilig for assistance with data management and quality control. Lastly, we thank all participants and their families for their enduring commitment to the study over the years. Open Access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2024 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
PY - 2024/2/24
Y1 - 2024/2/24
N2 - Adolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist in psychopathology, which might be mirrored in underlying sex differences in structural development. However, previous studies showed inconsistencies in subcortical trajectories and potential sex differences. Therefore, we aimed to investigate the subcortical structural trajectories and their sex differences across adolescence using for the first time a single cohort design, the same quality control procedure, software, and a general additive mixed modeling approach. We investigated two large European sites from ages 14 to 24 with 503 participants and 1408 total scans from France and Germany as part of the IMAGEN project including four waves of data acquisition. We found significantly larger volumes in males versus females in both sites and across all seven subcortical regions. Sex differences in age-related trajectories were observed across all regions in both sites. Our findings provide further evidence of sex differences in longitudinal adolescent brain development of subcortical regions and thus might eventually support the relationship of underlying brain development and different adolescent psychopathology in boys and girls.
AB - Adolescent subcortical structural brain development might underlie psychopathological symptoms, which often emerge in adolescence. At the same time, sex differences exist in psychopathology, which might be mirrored in underlying sex differences in structural development. However, previous studies showed inconsistencies in subcortical trajectories and potential sex differences. Therefore, we aimed to investigate the subcortical structural trajectories and their sex differences across adolescence using for the first time a single cohort design, the same quality control procedure, software, and a general additive mixed modeling approach. We investigated two large European sites from ages 14 to 24 with 503 participants and 1408 total scans from France and Germany as part of the IMAGEN project including four waves of data acquisition. We found significantly larger volumes in males versus females in both sites and across all seven subcortical regions. Sex differences in age-related trajectories were observed across all regions in both sites. Our findings provide further evidence of sex differences in longitudinal adolescent brain development of subcortical regions and thus might eventually support the relationship of underlying brain development and different adolescent psychopathology in boys and girls.
UR - http://www.scopus.com/inward/record.url?scp=85185862128&partnerID=8YFLogxK
U2 - 10.1002/hbm.26574
DO - 10.1002/hbm.26574
M3 - Article
C2 - 38401132
SN - 1065-9471
VL - 45
SP - e26574
JO - Human Brain Mapping
JF - Human Brain Mapping
IS - 3
M1 - e26574
ER -