Adrenocortical adenomas with regression and myelolipomatous changes: urinary steroid profiling supports a distinctive benign neoplasm

Victoria Perna, Fabian Norman-Taylor, Dorota Dworakowska, Klaus-Martin Schulte, Simon Aylwin, Fatima Al-Hashimi, Salvador J. Diaz-Cano*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)


    Background: Adrenocortical neoplasms are classically divided into adenomas (ACA) and carcinomas (ACC). Heterogeneous appearance and greater size are criteria to suggest malignancy, along with the urinary steroid profile (USP). The presence of regression and myelolipomatous changes in adenomas (ACA-RML) can contribute to confusion with ACC and its USP remains unknown.

    Objective: To evaluate the features of ACA-RML in comparison with other adrenocortical neoplasms.

    Methods: We selected consecutive ACA (11), ACA-RML (7) and ACC (13) cases for which USP analysis was performed before surgery and tissue was available for histological evaluation (King's College Hospital, 2005-2012). Cases were classified according to WHO and Armed Forces Institute of Pathology criteria. USPs were obtained by gas chromatography/mass spectrometry. Total excretion of individual steroids and indices (sums and ratios chosen to reflect steroid metabolic activity) were compared between ACA-RML, ACA and ACC.

    Results: In comparison with ACA, tumours in ACA-RML were significantly larger (8.5 +/- 2.4 vs 3.5 +/- 1.0, P = 0.002), presented in older patients and showed relatively higher incidence in males. Mitotic figure counts were significantly lower (0.39 +/- 0.04 vs 0.93 +/- 0.11 in ACA, P = 0.001) and revealed higher frequency of apoptotic cells (100% vs 9% in ACA, P = 0.001). The USP of ACA-RML showed no diagnostic features of ACC. No differences from ACA were significant, but there was a tendency towards lower dehydroepiandrosterone DHA and DHA metabolites.

    Conclusions: ACA-RML reveals distinctive histological features and lack of USP markers of malignancy. More cases of this rare tumour may confirm differences from ACA in steroid excretion. It is important to recognize ACA-RML because its size and heterogeneous appearance raise the possibility of ACC.

    Original languageEnglish
    Pages (from-to)343-349
    Number of pages7
    JournalClinical endocrinology
    Issue number3
    Publication statusPublished - Sept 2014


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