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Adrenomedullin and Galanin Responses to Orthostasis in Older Persons

Research output: Contribution to journalArticle

James Broadbent, Johannes Reichmuth, Irhad Trozic, Markus Kneihsl, Andreas Rössler, David A Green, Joel Rodriguez, Helmut Hinghofer-Szalkay, Franz Fazekas, Nandu Goswami

Original languageEnglish
JournalEuropean Journal of Clinical Investigation
Early online date2 Sep 2017
Publication statusE-pub ahead of print - 2 Sep 2017


  • Adrenomedullin and Galanin Responses_BROADBENT_Publishedonline10August2017_GREEN AAM

    Adrenomedullin_and_Galanin_Responses_BROADBENT_Publishedonline10August2017_GREEN_AAM.pdf, 269 KB, application/pdf


    Accepted author manuscript


    This is the peer reviewed version of this article, published online in European Journal of Clinical Investigation, © Wiley 2017, which has been published in final form at This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

King's Authors


BACKGROUND: Neuroendocrine responses to orthostasis may be critical in the maintenance of mean arterial pressure in healthy individuals. A greater reduction in orthostatic tolerance with age may relate to modulation of hormonal responses such as adrenomedullin and galanin. Thus, we investigated 1) whether adrenomedullin and galanin concentrations increase during orthostatic challenge in older subjects, 2) whether adrenomedullin and galanin concentrations are higher in older females compared with older males when seated and during orthostatic challenge, and 3) whether postural changes in plasma concentrations of galanin are correlated with levels of adrenomedullin in either older females or males.

MATERIALS AND METHODS: Subjects (n=18; 12 ♀; 55-80 years old) performed a sit-to-stand test in a 25°C sensory-minimised environment, with blood samples collected after 4 mins of being seated and then when standing. Plasma adrenomedullin and galanin concentrations were determined.

RESULTS: Baseline plasma concentration of adrenomedullin (5.35 ± 0.74 (n=12, females) vs. 7.40 ± 1.06 pg/ml (n=5, males)) and galanin (64.07 ± 9.05 vs. 98.99 ± 16.90 pg/ml, respectively) did not significantly differ between genders. Furthermore, plasma adrenomedullin and galanin concentrations were not significantly affected by adoption of the upright posture in either gender, and were not correlated in females or males.

CONCLUSIONS: Adrenomedullin and galanin concentrations were similar between genders and did not change following adoption of the standing posture. To further clarify the roles these hormones play in orthostatic intolerance, adrenomedullin and galanin concentrations should be assessed in participants who show presyncopal symptoms during an orthostatic challenge. This article is protected by copyright. All rights reserved.

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