Adult Hippocampal Neurogenesis in Major Depressive Disorder & Alzheimer’s Disease

Thomas Berger; Hyun Ah Lee; Allan Young; Dag Aarsland; Sandrine Thuret

Adult Hippocampal Neurogenesis in Major Depressive Disorder & Alzheimer’s Disease

Thomas Berger, Hyun Ah Lee, Allan Young, Dag Aarsland, Sandrine Thuret

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Abstract

Depression and dementia are major public health problems. Major Depressive Disorder (MDD) and Alzheimer’s Disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.

Original language	English
Journal	TRENDS IN MOLECULAR MEDICINE
Publication status	Accepted/In press - 31 Mar 2020

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Berger et al TMM_ accepted_PUREAccepted author manuscript, 3.92 MBLicence: CC BY-NC-ND

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title = "Adult Hippocampal Neurogenesis in Major Depressive Disorder & Alzheimer{\textquoteright}s Disease",

abstract = "Depression and dementia are major public health problems. Major Depressive Disorder (MDD) and Alzheimer{\textquoteright}s Disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD. ",

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year = "2020",

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T1 - Adult Hippocampal Neurogenesis in Major Depressive Disorder & Alzheimer’s Disease

AU - Berger, Thomas

AU - Lee, Hyun Ah

AU - Young, Allan

AU - Aarsland, Dag

AU - Thuret, Sandrine

PY - 2020/3/31

Y1 - 2020/3/31

N2 - Depression and dementia are major public health problems. Major Depressive Disorder (MDD) and Alzheimer’s Disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.

AB - Depression and dementia are major public health problems. Major Depressive Disorder (MDD) and Alzheimer’s Disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.

M3 - Article

SN - 1471-4914

JO - TRENDS IN MOLECULAR MEDICINE

JF - TRENDS IN MOLECULAR MEDICINE

ER -

Adult Hippocampal Neurogenesis in Major Depressive Disorder & Alzheimer’s Disease

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