Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer's Disease

Thomas Berger; Hyunah Lee; Allan H. Young; Dag Aarsland; Sandrine Thuret

doi:10.1016/j.molmed.2020.03.010

Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer's Disease

Thomas Berger, Hyunah Lee, Allan H. Young, Dag Aarsland, Sandrine Thuret^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

153 Citations (Scopus)

Abstract

Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.

Original language	English
Pages (from-to)	803-818
Number of pages	16
Journal	TRENDS IN MOLECULAR MEDICINE
Volume	26
Issue number	9
DOIs	https://doi.org/10.1016/j.molmed.2020.03.010
Publication status	Published - Sept 2020

Keywords

adult hippocampal neurogenesis
Alzheimer's disease
major depressive disorder

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abstract = "Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.",

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AU - Berger, Thomas

AU - Lee, Hyunah

AU - Young, Allan H.

AU - Aarsland, Dag

AU - Thuret, Sandrine

PY - 2020/9

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N2 - Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.

AB - Depression and dementia are major public health problems. Major depressive disorder (MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No effective drug is available to treat AD and about one-third of depressive patients show treatment resistance. The biological connection between MDD and AD is still unclear. Uncovering this link might open novel ways of treatment and prevention to improve patient healthcare. Here, we discuss recent studies specifically on the role of human adult hippocampal neurogenesis (AHN) in MDD and AD. We compare diverse approaches to analyse the effect of MDD and AD on human AHN and analyse different studies implicating the role of human AHN as a potential converging mechanism in MDD and AD.

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Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer's Disease

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Keywords

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