Adult presentation of a PLAGL2-amplified neuroepithelial tumor mimicking glioblastoma: broadening the spectrum of a proposed entity

Zita Reisz; Nikhil Agarwal; Evangelos Anagnostou; Yasir A. Chowdhury; Kelly Eggleton; Rebecca Ellmers; Ross Laxton; Chirag Limbachia; Simon Lam; Kazumi Chia; Jose Pedro Lavrador; Keyoumars Ashkan; Safa Al-Sarraj; Istvan Bodi

doi:10.1186/s40478-026-02256-4

Adult presentation of a PLAGL2-amplified neuroepithelial tumor mimicking glioblastoma: broadening the spectrum of a proposed entity

Zita Reisz^*
, Nikhil Agarwal
, Evangelos Anagnostou
, Yasir A. Chowdhury
, Kelly Eggleton
, Rebecca Ellmers
, Ross Laxton
, Chirag Limbachia
, Simon Lam
, Kazumi Chia
, Jose Pedro Lavrador
, Keyoumars Ashkan
, Safa Al-Sarraj
, Istvan Bodi

^*Corresponding author for this work

Basic and Clinical Neuroscience

KCH King's College Hospital NHS Foundation Trust
GSTT Guy's and St Thomas' NHS Foundation Trust

Research output: Contribution to journal › Letter › peer-review

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Original language	English
Article number	68
Journal	Acta Neuropathologica Communications
Volume	14
Early online date	17 Feb 2026
DOIs	https://doi.org/10.1186/s40478-026-02256-4
Publication status	Published - 25 Mar 2026

Keywords

Copy number variation
Desmin
DNA methylation profiling
Embryonal tumor
Glioblastoma
IDH-wildtype
Pediatric CNS tumor
PLAGL-family amplification
PLAGL2
Temozolomide

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10.1186/s40478-026-02256-4Licence: CC BY-NC-ND

Adult presentation of a PLAGL2_VoRFinal published version, 1.51 MBLicence: CC BY-NC-ND

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Reisz, Z., Agarwal, N., Anagnostou, E., Chowdhury, Y. A., Eggleton, K., Ellmers, R., Laxton, R., Limbachia, C., Lam, S., Chia, K., Lavrador, J. P., Ashkan, K., Al-Sarraj, S., & Bodi, I. (2026). Adult presentation of a PLAGL2-amplified neuroepithelial tumor mimicking glioblastoma: broadening the spectrum of a proposed entity. Acta Neuropathologica Communications, 14, Article 68. https://doi.org/10.1186/s40478-026-02256-4

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title = "Adult presentation of a PLAGL2-amplified neuroepithelial tumor mimicking glioblastoma: broadening the spectrum of a proposed entity",

keywords = "Copy number variation, Desmin, DNA methylation profiling, Embryonal tumor, Glioblastoma, IDH-wildtype, Pediatric CNS tumor, PLAGL-family amplification, PLAGL2, Temozolomide",

author = "Zita Reisz and Nikhil Agarwal and Evangelos Anagnostou and Chowdhury, \{Yasir A.\} and Kelly Eggleton and Rebecca Ellmers and Ross Laxton and Chirag Limbachia and Simon Lam and Kazumi Chia and Lavrador, \{Jose Pedro\} and Keyoumars Ashkan and Safa Al-Sarraj and Istvan Bodi",

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day = "25",

doi = "10.1186/s40478-026-02256-4",

language = "English",

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Reisz, Z, Agarwal, N, Anagnostou, E, Chowdhury, YA, Eggleton, K, Ellmers, R, Laxton, R, Limbachia, C, Lam, S, Chia, K, Lavrador, JP, Ashkan, K , Al-Sarraj, S & Bodi, I 2026, 'Adult presentation of a PLAGL2-amplified neuroepithelial tumor mimicking glioblastoma: broadening the spectrum of a proposed entity', Acta Neuropathologica Communications, vol. 14, 68. https://doi.org/10.1186/s40478-026-02256-4

TY - JOUR

T1 - Adult presentation of a PLAGL2-amplified neuroepithelial tumor mimicking glioblastoma

T2 - broadening the spectrum of a proposed entity

AU - Reisz, Zita

AU - Agarwal, Nikhil

AU - Anagnostou, Evangelos

AU - Chowdhury, Yasir A.

AU - Eggleton, Kelly

AU - Ellmers, Rebecca

AU - Laxton, Ross

AU - Limbachia, Chirag

AU - Lam, Simon

AU - Chia, Kazumi

AU - Lavrador, Jose Pedro

AU - Ashkan, Keyoumars

AU - Al-Sarraj, Safa

AU - Bodi, Istvan

PY - 2026/3/25

Y1 - 2026/3/25

KW - Copy number variation

KW - Desmin

KW - DNA methylation profiling

KW - Embryonal tumor

KW - Glioblastoma

KW - IDH-wildtype

KW - Pediatric CNS tumor

KW - PLAGL-family amplification

KW - PLAGL2

KW - Temozolomide

UR - https://www.scopus.com/pages/publications/105034406603

U2 - 10.1186/s40478-026-02256-4

DO - 10.1186/s40478-026-02256-4

M3 - Letter

C2 - 41703662

AN - SCOPUS:105034406603

SN - 2051-5960

VL - 14

JO - Acta Neuropathologica Communications

JF - Acta Neuropathologica Communications

M1 - 68

ER -

Adult presentation of a PLAGL2-amplified neuroepithelial tumor mimicking glioblastoma: broadening the spectrum of a proposed entity

Keywords

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