Advanced paternal age increases the risk of schizophrenia and obsessive-compulsive disorder in a Chinese Han population

TY - JOUR

T1 - Advanced paternal age increases the risk of schizophrenia and obsessive-compulsive disorder in a Chinese Han population

AU - Wu, Yuejing

AU - Liu, Xiang

AU - Luo, Hongrong

AU - Deng, Wei

AU - Zhao, Gaofeng

AU - Wang, Qiang

AU - Zhang, Lan

AU - Ma, Xiaohong

AU - Liu, Xiehe

AU - Murray, Robin A.

AU - Collier, David A.

AU - Li, Tao

PY - 2012/8/15

Y1 - 2012/8/15

N2 - Using the Structured Clinical Interview for DSM-IV, patient and non-patient version (SCID-P/NP), this study investigated 351 patients with schizophrenia, 122 with obsessive-compulsive disorder (OCD), and 238 unrelated healthy volunteers in a Chinese Han population. The relative risks posed by advanced paternal age for schizophrenia and OCD in offspring were computed under logistic regression analyses and adjusted for the participant's sex, age and co-parent age at birth. Compared to the offspring with paternal age of 25-29 years old, the relative risks rose from 2.660 to 10.183 in the paternal age range of 30-34 and >= 35. The relative risks for OCD increased from 2.225 to 5.413 in 30-34 and >= 35. For offspring with paternal age of = 35 in male offspring were 2.407 and 10.893, and in female offspring were 3.080 and 9.659. The relative risks for OCD with paternal age of 30-34 and >= 35 in male offspring were 3.493 and 7373, and in female offspring 2.005 and 4.404. The mean paternal age of schizophrenia/OCD patients born before the early 1980s was much greater than that of patients who were born after then. The findings illustrated that advanced paternal age is associated with increased risk for both schizophrenia and OCD in a Chinese Han population, prominently when paternal age is over 35. Biological and non-biological mechanisms may both be involved in the effects of advanced paternal age on schizophrenia and OCD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

AB - Using the Structured Clinical Interview for DSM-IV, patient and non-patient version (SCID-P/NP), this study investigated 351 patients with schizophrenia, 122 with obsessive-compulsive disorder (OCD), and 238 unrelated healthy volunteers in a Chinese Han population. The relative risks posed by advanced paternal age for schizophrenia and OCD in offspring were computed under logistic regression analyses and adjusted for the participant's sex, age and co-parent age at birth. Compared to the offspring with paternal age of 25-29 years old, the relative risks rose from 2.660 to 10.183 in the paternal age range of 30-34 and >= 35. The relative risks for OCD increased from 2.225 to 5.413 in 30-34 and >= 35. For offspring with paternal age of = 35 in male offspring were 2.407 and 10.893, and in female offspring were 3.080 and 9.659. The relative risks for OCD with paternal age of 30-34 and >= 35 in male offspring were 3.493 and 7373, and in female offspring 2.005 and 4.404. The mean paternal age of schizophrenia/OCD patients born before the early 1980s was much greater than that of patients who were born after then. The findings illustrated that advanced paternal age is associated with increased risk for both schizophrenia and OCD in a Chinese Han population, prominently when paternal age is over 35. Biological and non-biological mechanisms may both be involved in the effects of advanced paternal age on schizophrenia and OCD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

KW - Paternal age

KW - Schizophrenia

KW - Obsessive-compulsive disorder

KW - Chinese population

KW - DE-NOVO MUTATIONS

KW - MALE GERM-CELLS

KW - PARENTAL AGE

KW - BIPOLAR-DISORDER

KW - SPORADIC SCHIZOPHRENIA

KW - EPIGENETIC REGULATION

KW - 1ST-DEGREE RELATIVES

KW - MENTAL-ILLNESS

KW - FAMILY-HISTORY

KW - BIRTH

U2 - 10.1016/j.psychres.2012.01.020

DO - 10.1016/j.psychres.2012.01.020

M3 - Article

SN - 0165-1781

VL - 198

SP - 353

EP - 359

JO - Psychiatry Research

JF - Psychiatry Research

IS - 3

ER -