Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders

Martien J. H. Kas; Vaishnav Krishnan; Todd D. Gould; David A. Collier; Berend Olivier; Klaus-Peter Lesch; Enrico Domenici; Eberhard Fuchs; Cornelius Gross; Eero Castren

doi:10.1016/j.euroneuro.2010.12.001

Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders

Martien J. H. Kas, Vaishnav Krishnan, Todd D. Gould, David A. Collier, Berend Olivier, Klaus-Peter Lesch, Enrico Domenici, Eberhard Fuchs, Cornelius Gross, Eero Castren

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Current approaches to dissect the molecular neurobiology of complex neuropsychiatric disorders such as schizophrenia and major depression have been rightly criticized for failing to provide benefits to patients. Improving the translational potential of our efforts will require the development and refinement of better disease models that consider a wide variety of contributing factors, such as genetic variation, gene-by-environment interactions, endophenotype or intermediate phenotype assessment, cross species analysis, sex differences, and developmental stages. During a targeted expert meeting of the European College of Neuropsychopharmacology (ECNP) in Istanbul, we addressed the opportunities and pitfalls of current translational animal models of psychiatric disorders and agreed on a series of core guidelines and recommendations that we believe will help guiding further research in this area. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.

Original language	English
Pages (from-to)	532 - 544
Number of pages	13
Journal	European Neuropsychopharmacology
Volume	21
Issue number	7
DOIs	https://doi.org/10.1016/j.euroneuro.2010.12.001
Publication status	Published - Jul 2011

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10.1016/j.euroneuro.2010.12.001

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title = "Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders",

abstract = "Current approaches to dissect the molecular neurobiology of complex neuropsychiatric disorders such as schizophrenia and major depression have been rightly criticized for failing to provide benefits to patients. Improving the translational potential of our efforts will require the development and refinement of better disease models that consider a wide variety of contributing factors, such as genetic variation, gene-by-environment interactions, endophenotype or intermediate phenotype assessment, cross species analysis, sex differences, and developmental stages. During a targeted expert meeting of the European College of Neuropsychopharmacology (ECNP) in Istanbul, we addressed the opportunities and pitfalls of current translational animal models of psychiatric disorders and agreed on a series of core guidelines and recommendations that we believe will help guiding further research in this area. (C) 2010 Elsevier B.V. and ECNP. All rights reserved.",

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AU - Kas, Martien J. H.

AU - Krishnan, Vaishnav

AU - Gould, Todd D.

AU - Collier, David A.

AU - Olivier, Berend

AU - Lesch, Klaus-Peter

AU - Domenici, Enrico

AU - Fuchs, Eberhard

AU - Gross, Cornelius

AU - Castren, Eero

PY - 2011/7

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DO - 10.1016/j.euroneuro.2010.12.001

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JO - European Neuropsychopharmacology

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Advances in multidisciplinary and cross-species approaches to examine the neurobiology of psychiatric disorders

Abstract

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