Advances in paediatric pulmonary vascular disease associated with bronchopulmonary dysplasia

Thomas Rossor, Anne Greenough*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Pulmonary hypertension (PH) is a common finding in infants with bronchopulmonary dysplasia (BPD). The aim of this review is to describe recent advances in the diagnosis and treatment of PH and discuss whether they will benefit infants and children with BPD related PH. Echocardiography remains the mainstay of diagnosis but has limitations, further developments in diagnostic techniques and identification of biomarkers are required. There are many potential therapies for PH associated with BPD. Inhaled nitric oxide has been shown to improve short term outcomes only. Sidenafil in resource limited settings was shown in three randomized trials to significantly reduce mortality. The efficacy of other therapies including prostacyclin, PDE3 inhibitors and endothelin receptor blockers has only been reported in case reports or case series. Randomized controlled trials with long term follow up are required to appropriately assess the efficacy of therapies aimed at improving the outcome of children with PH.

Original languageEnglish
Pages (from-to)35-43
Number of pages9
JournalExpert review of respiratory medicine
Volume9
Issue number1
DOIs
Publication statusPublished - 1 Feb 2015

Keywords

  • Bronchopulmonary dysplasia
  • pulmonary hypertension
  • pulmonary vascular disease

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