Advances in repairing the degenerate retina by rod photoreceptor transplantation

Rachael A. Pearson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Citations (Scopus)

Abstract

Despite very different aetiologies, age-related macular degeneration (AMD) and most inherited retinal disorders culminate in the same final common pathway, loss of the light-sensitive photoreceptors. There are few clinical treatments and none can reverse the loss of vision. Photoreceptor replacement by transplantation is proposed as a broad treatment strategy applicable to all degenerations. The past decade has seen a number of landmark achievements in this field, which together provide strong justification for continuing investigation into photoreceptor replacement strategies. These include proof of principle for restoring vision by rod-photoreceptor transplantation in mice with congenital stationary night blindness and advances in stem cell biology, which have led to the generation of complete optic structures in vitro from embryonic stem cells. The latter represents enormous potential for generating suitable and renewable donor cells with which to achieve the former. However, there are still challenges presented by the degenerating recipient retinal environment that must be addressed as we move to translating these technologies towards clinical application.

Original languageEnglish
Pages (from-to)485-491
Number of pages7
JournalBIOTECHNOLOGY ADVANCES
Volume32
Issue number2
DOIs
Publication statusPublished - Mar 2014

Keywords

  • Degeneration
  • Development
  • Eye
  • Gliosis
  • Neural retina
  • Photoreceptor
  • Stem cells
  • Transplantation
  • Visual function

Fingerprint

Dive into the research topics of 'Advances in repairing the degenerate retina by rod photoreceptor transplantation'. Together they form a unique fingerprint.

Cite this