Advances in the Relationships Between Cow’s Milk Protein Allergy and Gut Microbiota in Infants

TY - JOUR

T1 - Advances in the Relationships Between Cow’s Milk Protein Allergy and Gut Microbiota in Infants

AU - Yang, Yudie

AU - Li, Xiaoqi

AU - Yang, Ying

AU - Shoaie, Saeed

AU - Zhang, Cheng

AU - Ji, Boyang

AU - Wei, Yongjun

N1 - Funding Information: This work was supported by Henan Provincial Key Laboratory of Children’s Genetics and Metabolic Diseases Foundation (No. SS201909), the National Natural Science Foundation of China (Nos. 31800079 and 32111530179), and Clinical Laboratories, Shenyou Bio. Funding Information: We would like to thank TopEdit (www.topeditsci.com) for the English language editing of this manuscript. Funding. This work was supported by Henan Provincial Key Laboratory of Children?s Genetics and Metabolic Diseases Foundation (No. SS201909), the National Natural Science Foundation of China (Nos. 31800079 and 32111530179), and Clinical Laboratories, Shenyou Bio. Publisher Copyright: © Copyright © 2021 Yang, Li, Yang, Shoaie, Zhang, Ji and Wei. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/8/16

Y1 - 2021/8/16

N2 - Cow’s milk protein allergy (CMPA) is an immune response to cow’s milk proteins, which is one of the most common food allergies in infants and young children. It is estimated that 2–3% of infants and young children have CMPA. The diet, gut microbiota, and their interactions are believed to be involved in the alterations of mucosal immune tolerance, which might lead to the development of CMPA and other food allergies. In this review, the potential molecular mechanisms of CMPA, including omics technologies used for analyzing microbiota, impacts of early microbial exposures on CMPA development, and microbiota–host interactions, are summarized. The probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and other modulation strategies for gut microbiota and the potential application of microbiota-based design of diets for the CMPA treatment are also discussed. This review not only summarizes the current studies about the interactions of CMPA with gut microbiota but also gives insights into the possible CMPA treatment strategies by modulating gut microbiota, which might help in improving the life quality of CMPA patients in the future.

AB - Cow’s milk protein allergy (CMPA) is an immune response to cow’s milk proteins, which is one of the most common food allergies in infants and young children. It is estimated that 2–3% of infants and young children have CMPA. The diet, gut microbiota, and their interactions are believed to be involved in the alterations of mucosal immune tolerance, which might lead to the development of CMPA and other food allergies. In this review, the potential molecular mechanisms of CMPA, including omics technologies used for analyzing microbiota, impacts of early microbial exposures on CMPA development, and microbiota–host interactions, are summarized. The probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and other modulation strategies for gut microbiota and the potential application of microbiota-based design of diets for the CMPA treatment are also discussed. This review not only summarizes the current studies about the interactions of CMPA with gut microbiota but also gives insights into the possible CMPA treatment strategies by modulating gut microbiota, which might help in improving the life quality of CMPA patients in the future.

KW - cow’s milk allergy

KW - fecal microbiota transplantation

KW - gut microbiota

KW - prebiotics

KW - probiotics

KW - synthetic microbiota

UR - http://www.scopus.com/inward/record.url?scp=85114234126&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2021.716667

DO - 10.3389/fmicb.2021.716667

M3 - Review article

AN - SCOPUS:85114234126

SN - 1664-302X

VL - 12

JO - Frontiers in microbiology

JF - Frontiers in microbiology

M1 - 716667

ER -