Adverse reactions to COVID-19 vaccines: A practical approach

TY - JOUR

T1 - Adverse reactions to COVID-19 vaccines

T2 - A practical approach

AU - Rutkowski, Krzysztof

AU - Mirakian, Rita

AU - Till, Stephen

AU - Rutkowski, Ryszard

AU - Wagner, Annette

N1 - Publisher Copyright: © 2021 John Wiley & Sons Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/6

Y1 - 2021/6

N2 - COVID-19-related mortality in high-risk individuals is substantial and current treatment options are limited. There is convincing evidence that the COVID-19 vaccines reduce the severity of infection and prevent deaths. Three COVID-19 vaccines are approved in the United Kingdom with many more in development. There are limited data on the triggers and mechanisms of anaphylaxis to these vaccines. We review the potential allergenic compounds in the COVID-19 vaccines and describe an innovative allergy support model for the vaccination hubs that allows most patients with severe allergy be immunized. Finally, we propose a practical algorithm for the investigations of anaphylaxis to these vaccines.

AB - COVID-19-related mortality in high-risk individuals is substantial and current treatment options are limited. There is convincing evidence that the COVID-19 vaccines reduce the severity of infection and prevent deaths. Three COVID-19 vaccines are approved in the United Kingdom with many more in development. There are limited data on the triggers and mechanisms of anaphylaxis to these vaccines. We review the potential allergenic compounds in the COVID-19 vaccines and describe an innovative allergy support model for the vaccination hubs that allows most patients with severe allergy be immunized. Finally, we propose a practical algorithm for the investigations of anaphylaxis to these vaccines.

UR - http://www.scopus.com/inward/record.url?scp=85104530750&partnerID=8YFLogxK

U2 - 10.1111/cea.13880

DO - 10.1111/cea.13880

M3 - Review article

C2 - 33813758

AN - SCOPUS:85104530750

SN - 0954-7894

VL - 51

SP - 770

EP - 777

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

IS - 6

ER -