Age-effects in white matter using associated diffusion tensor imaging and magnetization transfer ratio during late childhood and early adolescence

Luciana Monteiro Moura, Matthew Kempton, Gareth Barker, Giovanni Salum, Ary Gadelha, Pedro Mario Pan, Marcelo Hoexter, Marco Antonio Gomes Del Aquilla, Felipe Almeida Picon, Mauricio Anés, Maria Concepcion Garcia Otaduy, Edson Amaro, Luis Augusto Rohde, Philip McGuire, Rodrigo Affonseca Bressan, João Ricardo Sato, Andrea Parolin Jackowski

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25 Citations (Scopus)
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Abstract

In the last decade, several studies have described the typical brain white matter maturation in children and adolescents. Diffusion tensor imaging (DTI) is the most frequent MRI technique used to investigate the structural changes across development. However, few previous studies have used the magnetization transfer ratio (MTR), which gives a closer measure of myelin content. Here, we employed both techniques for the same sample of 176 typically developing children from 7 to 14years of age. We investigated the associations between DTI parameters and MTR measure, to assess the myelination in the brain in development. Secondly, we investigated age-effects on DTI parameters (fractional anisotropy, axial, radial and mean diffusivities) and MTR. No significant correlations between MTR and DTI parameters were observed. In addition, a significant age-effect was detected for DTI data but was not visible for MTR data. Thereby, changes in white matter at this age might be primarily correlated with microstructural changes.

Original languageEnglish
JournalMagnetic resonance imaging
DOIs
Publication statusPublished - 17 Dec 2015

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