Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy

TY - JOUR

T1 - Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy

AU - Charge, S B P

AU - Brack, A S

AU - Hughes, S M

PY - 2002/10

Y1 - 2002/10

N2 - To investigate the cause of skeletal muscle weakening during aging we examined the sequence of cellular changes in murine muscles. Satellite cells isolated from single muscle fibers terminally differentiate progressively less well with increasing age of donor. This change is detected before decline in satellite cell numbers and all histological changes examined here. In MSVski transgenic mice, which show type IIb fiber hypertrophy, initial muscle weakness is followed by muscle degeneration in the first year of life. This degeneration is accompanied by a spectrum of changes typical of normal muscle aging and a more marked decline in satellite cell differentiation efficiency. On a myoD-null genetic background, in which satellite cell differentiation is defective, the MSVski muscle phenotype is aggravated. This suggests that, on a wild-type genetic background, satellite cells are capable of repairing MSVski fibers and preserving muscle integrity in early life. We propose that decline in myogenic cell differentiation efficiency is an early event in aging-related loss of muscle function, both in normal aging and in some late-onset muscle degenerative conditions.

AB - To investigate the cause of skeletal muscle weakening during aging we examined the sequence of cellular changes in murine muscles. Satellite cells isolated from single muscle fibers terminally differentiate progressively less well with increasing age of donor. This change is detected before decline in satellite cell numbers and all histological changes examined here. In MSVski transgenic mice, which show type IIb fiber hypertrophy, initial muscle weakness is followed by muscle degeneration in the first year of life. This degeneration is accompanied by a spectrum of changes typical of normal muscle aging and a more marked decline in satellite cell differentiation efficiency. On a myoD-null genetic background, in which satellite cell differentiation is defective, the MSVski muscle phenotype is aggravated. This suggests that, on a wild-type genetic background, satellite cells are capable of repairing MSVski fibers and preserving muscle integrity in early life. We propose that decline in myogenic cell differentiation efficiency is an early event in aging-related loss of muscle function, both in normal aging and in some late-onset muscle degenerative conditions.

UR - http://www.scopus.com/inward/record.url?scp=0036784164&partnerID=8YFLogxK

U2 - 10.1152/ajpcell.00206.2002

DO - 10.1152/ajpcell.00206.2002

M3 - Article

VL - 283

SP - C1228 - C1241

JO - AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

JF - AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IS - 4

ER -