Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans

A F Behndig, I S Mudway, J L Brown, N Stenfors, R Helleday, S T Duggan, S J Wilson, C Boman, F R Cassee, A J Frew, F J Kelly, T Sandstrom, A Blomberg

Research output: Contribution to journalArticlepeer-review

201 Citations (Scopus)

Abstract

Pulmonary cells exposed to diesel exhaust (DE) particles in vitro respond in a hierarchical fashion with protective antioxidant responses predominating at low doses and inflammation and injury only occurring at higher concentrations. In the present study, the authors examined whether similar responses occurred in vivo, specifically whether antioxidants were upregulated following a low-dose DE challenge and investigated how these responses related to the development of airway inflammation at different levels of the respiratory tract where particle dose varies markedly. A total of 15 volunteers were exposed to DE (100 mu g.m(-3) airborne particulate matter with a diameter of
Original languageEnglish
Pages (from-to)359 - 365
Number of pages7
JournalEuropean Respiratory Journal
Volume27
Issue number2
DOIs
Publication statusPublished - Feb 2006

Fingerprint

Dive into the research topics of 'Airway antioxidant and inflammatory responses to diesel exhaust exposure in healthy humans'. Together they form a unique fingerprint.

Cite this