Abstract
Pulmonary cells exposed to diesel exhaust (DE) particles in vitro respond in a hierarchical fashion with protective antioxidant responses predominating at low doses and inflammation and injury only occurring at higher concentrations. In the present study, the authors examined whether similar responses occurred in vivo, specifically whether antioxidants were upregulated following a low-dose DE challenge and investigated how these responses related to the development of airway inflammation at different levels of the respiratory tract where particle dose varies markedly. A total of 15 volunteers were exposed to DE (100 mu g.m(-3) airborne particulate matter with a diameter of
Original language | English |
---|---|
Pages (from-to) | 359 - 365 |
Number of pages | 7 |
Journal | European Respiratory Journal |
Volume | 27 |
Issue number | 2 |
DOIs | |
Publication status | Published - Feb 2006 |