Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium

C. C. Dahm; R. H. Keogh; P. N. Mitrou; B. J. Cairns; D. C. Greenwood; E. A. Spencer; Ian Fentiman; M. J. Shipley; E. J. Brunner; J. E. Cade; V. J. Burley; G. D. Mishra; D. Kuh; A. M. Stephen; I. R. White; R. N. Luben; A. A. Mulligan; K-T Khaw; S. A. Rodwell

doi:10.1038/sj.bjc.6605802

Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium

C. C. Dahm, R. H. Keogh, P. N. Mitrou, B. J. Cairns, D. C. Greenwood, E. A. Spencer, Ian Fentiman, M. J. Shipley, E. J. Brunner, J. E. Cade, V. J. Burley, G. D. Mishra, D. Kuh, A. M. Stephen, I. R. White, R. N. Luben, A. A. Mulligan, K-T Khaw^*, S. A. Rodwell

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent.

METHODS: We investigated the prospective associations between alcohol intake on overall and site-and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ).

RESULTS: Compared with individuals in the lightest category of drinkers (>0-= 45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results.

CONCLUSION: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.

Original language	English
Pages (from-to)	747-756
Number of pages	10
Journal	BJC: British Journal of Cancer
Volume	103
Issue number	5
DOIs	https://doi.org/10.1038/sj.bjc.6605802
Publication status	Published - 24 Aug 2010

Keywords

colorectal cancer
alcohol intake
prospective cohort study
food diary
food frequency questionnaire
FOOD-FREQUENCY QUESTIONNAIRE
EPIC-NORFOLK COHORT
POOLED ANALYSIS
BREAST-CANCER
WHITEHALL-II
DISTAL COLON
MEAT-EATERS
7-DAY DIARY
CONSUMPTION
DRINKING

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6605802

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Dahm, C. C., Keogh, R. H., Mitrou, P. N., Cairns, B. J., Greenwood, D. C., Spencer, E. A., Fentiman, I., Shipley, M. J., Brunner, E. J., Cade, J. E., Burley, V. J., Mishra, G. D., Kuh, D., Stephen, A. M., White, I. R., Luben, R. N., Mulligan, A. A., Khaw, K.-T., & Rodwell, S. A. (2010). Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium. BJC: British Journal of Cancer, 103(5), 747-756. https://doi.org/10.1038/sj.bjc.6605802

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abstract = "BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent.METHODS: We investigated the prospective associations between alcohol intake on overall and site-and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ).RESULTS: Compared with individuals in the lightest category of drinkers (>0-= 45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results.CONCLUSION: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.",

keywords = "colorectal cancer, alcohol intake, prospective cohort study, food diary, food frequency questionnaire, FOOD-FREQUENCY QUESTIONNAIRE, EPIC-NORFOLK COHORT, POOLED ANALYSIS, BREAST-CANCER, WHITEHALL-II, DISTAL COLON, MEAT-EATERS, 7-DAY DIARY, CONSUMPTION, DRINKING",

author = "Dahm, {C. C.} and Keogh, {R. H.} and Mitrou, {P. N.} and Cairns, {B. J.} and Greenwood, {D. C.} and Spencer, {E. A.} and Ian Fentiman and Shipley, {M. J.} and Brunner, {E. J.} and Cade, {J. E.} and Burley, {V. J.} and Mishra, {G. D.} and D. Kuh and Stephen, {A. M.} and White, {I. R.} and Luben, {R. N.} and Mulligan, {A. A.} and K-T Khaw and Rodwell, {S. A.}",

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doi = "10.1038/sj.bjc.6605802",

language = "English",

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Dahm, CC, Keogh, RH, Mitrou, PN, Cairns, BJ, Greenwood, DC, Spencer, EA, Fentiman, I, Shipley, MJ, Brunner, EJ, Cade, JE, Burley, VJ, Mishra, GD, Kuh, D, Stephen, AM, White, IR, Luben, RN, Mulligan, AA, Khaw, K-T & Rodwell, SA 2010, 'Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium', BJC: British Journal of Cancer, vol. 103, no. 5, pp. 747-756. https://doi.org/10.1038/sj.bjc.6605802

TY - JOUR

T1 - Alcohol intake and risk of colorectal cancer

T2 - Results from the UK Dietary Cohort Consortium

AU - Dahm, C. C.

AU - Keogh, R. H.

AU - Mitrou, P. N.

AU - Cairns, B. J.

AU - Greenwood, D. C.

AU - Spencer, E. A.

AU - Fentiman, Ian

AU - Shipley, M. J.

AU - Brunner, E. J.

AU - Cade, J. E.

AU - Burley, V. J.

AU - Mishra, G. D.

AU - Kuh, D.

AU - Stephen, A. M.

AU - White, I. R.

AU - Luben, R. N.

AU - Mulligan, A. A.

AU - Khaw, K-T

AU - Rodwell, S. A.

PY - 2010/8/24

Y1 - 2010/8/24

N2 - BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent.METHODS: We investigated the prospective associations between alcohol intake on overall and site-and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ).RESULTS: Compared with individuals in the lightest category of drinkers (>0-= 45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results.CONCLUSION: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.

AB - BACKGROUND: Epidemiological studies have suggested that excessive alcohol intake increases colorectal cancer (CRC) risk. However, findings regarding tumour subsites and sex differences have been inconsistent.METHODS: We investigated the prospective associations between alcohol intake on overall and site-and sex-specific CRC risk. Analyses were conducted on 579 CRC cases and 1996 matched controls nested within the UK Dietary Cohort Consortium using standardised data obtained from food diaries as a main nutritional method and repeated using data from food frequency questionnaire (FFQ).RESULTS: Compared with individuals in the lightest category of drinkers (>0-= 45 g per day. No clear associations were observed between site-specific CRC risk and alcohol intake in either sex. Analyses using FFQ showed similar results.CONCLUSION: We found no significantly increased risk of CRC up to 30 g per day of alcohol intake within the UK Dietary Cohort Consortium.

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KW - alcohol intake

KW - prospective cohort study

KW - food diary

KW - food frequency questionnaire

KW - FOOD-FREQUENCY QUESTIONNAIRE

KW - EPIC-NORFOLK COHORT

KW - POOLED ANALYSIS

KW - BREAST-CANCER

KW - WHITEHALL-II

KW - DISTAL COLON

KW - MEAT-EATERS

KW - 7-DAY DIARY

KW - CONSUMPTION

KW - DRINKING

U2 - 10.1038/sj.bjc.6605802

DO - 10.1038/sj.bjc.6605802

M3 - Article

SN - 0007-0920

VL - 103

SP - 747

EP - 756

JO - BJC: British Journal of Cancer

JF - BJC: British Journal of Cancer

IS - 5

ER -

Alcohol intake and risk of colorectal cancer: Results from the UK Dietary Cohort Consortium

Abstract

Keywords

UN SDGs

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