ALK and GSK3: shared features of neuroblastoma and neural crest cells

Sandra G Gonzalez Malagon; Karen J Liu

doi:10.1177/1179069518792499

ALK and GSK3: shared features of neuroblastoma and neural crest cells

Sandra G Gonzalez Malagon, Karen J Liu

Centre for Craniofacial & Regenerative Biology

Research output: Contribution to journal › Article › peer-review

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Abstract

Neuroblastoma is one of the most common and deadly childhood cancers. Neuroblastoma arises from transformed cells of the neural crest lineage. Outcomes of the disease vary greatly, ranging from spontaneous regression to aggressive metastases. While this variability may reflect the inherent migratory capabilities and multipotency of neural crest cells, there have been few direct comparisons between neuroblastoma and embryonic neural crest cells, in part because of the limited in vivo accessibility of the mammalian neural crest lineage. Our recent studies demonstrate a novel link between anaplastic lymphoma kinase (ALK) and glycogen synthase kinase 3 (GSK3). Our work suggests that ALK-dependent regulation of GSK3 via tyrosine phosphorylation may alter the substrate specificity of GSK3, thus regulating cytoskeletal dynamics in migrating neural crest cells.

Original language	English
Journal	Journal of Experimental Neuroscience
Volume	12
Early online date	13 Aug 2018
DOIs	https://doi.org/10.1177/1179069518792499
Publication status	Published - 2018

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ALK and GSK3_GONZALEZ MALAGON_Accepted12July2018_GOLD AAMAccepted author manuscript, 172 KB
ALK and GSK3_GONZALEZ MALAGON_Accepted12July2018_GOLD VoRFinal published version, 235 KBLicence: CC BY-NC

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abstract = "Neuroblastoma is one of the most common and deadly childhood cancers. Neuroblastoma arises from transformed cells of the neural crest lineage. Outcomes of the disease vary greatly, ranging from spontaneous regression to aggressive metastases. While this variability may reflect the inherent migratory capabilities and multipotency of neural crest cells, there have been few direct comparisons between neuroblastoma and embryonic neural crest cells, in part because of the limited in vivo accessibility of the mammalian neural crest lineage. Our recent studies demonstrate a novel link between anaplastic lymphoma kinase (ALK) and glycogen synthase kinase 3 (GSK3). Our work suggests that ALK-dependent regulation of GSK3 via tyrosine phosphorylation may alter the substrate specificity of GSK3, thus regulating cytoskeletal dynamics in migrating neural crest cells.",

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AU - Liu, Karen J

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AB - Neuroblastoma is one of the most common and deadly childhood cancers. Neuroblastoma arises from transformed cells of the neural crest lineage. Outcomes of the disease vary greatly, ranging from spontaneous regression to aggressive metastases. While this variability may reflect the inherent migratory capabilities and multipotency of neural crest cells, there have been few direct comparisons between neuroblastoma and embryonic neural crest cells, in part because of the limited in vivo accessibility of the mammalian neural crest lineage. Our recent studies demonstrate a novel link between anaplastic lymphoma kinase (ALK) and glycogen synthase kinase 3 (GSK3). Our work suggests that ALK-dependent regulation of GSK3 via tyrosine phosphorylation may alter the substrate specificity of GSK3, thus regulating cytoskeletal dynamics in migrating neural crest cells.

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JO - Journal of Experimental Neuroscience

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ALK and GSK3: shared features of neuroblastoma and neural crest cells

Abstract

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