All-optical dual photoacoustic and optical coherence tomography intravascular probe

Sunish J. Mathews*, Callum Little, Christopher D. Loder, Roby D. Rakhit, Wenfeng Xia, Edward Z. Zhang, Paul C. Beard, Malcolm C. Finlay, Adrien E. Desjardins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)
135 Downloads (Pure)

Abstract

Intravascular imaging in percutaneous coronary interventions can be an invaluable tool in the treatment of coronary artery disease. It is of significant interest to provide molecular imaging contrast that is complementary to structural contrast provided by optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). In this study, we developed a dual-modality intravascular imaging probe comprising a commercial OCT catheter and a high sensitivity fiber optic ultrasound sensor, to provide both photoacoustic (PA) and OCT imaging. With PA imaging, the lateral resolution varied from 18 μm to 40 μm; the axial resolution was consistently in the vicinity of 45 μm. We demonstrated the clinical potential of the probe with 2-D circumferential PA and OCT imaging, and with multispectral PA imaging.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalPhotoacoustics
Volume11
Early online date24 Jul 2018
DOIs
Publication statusPublished - 1 Sept 2018

Keywords

  • All-optical intravascular catheter
  • Endoscopic imaging
  • Fiber optic ultrasound sensor
  • Intravascular photoacoustic imaging
  • Optical coherence tomography

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