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Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review

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Sangeeta Dhami, Ulugbek Nurmatov, Giovanni Battista Pajno, Montserrat Fernandez-rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-lozano, Kirsten Beyer, Carsten Bindslev-jensen, Wesley Burks, George Du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela, Kari Christine Nadeau, Liam O’mahony, Nikolaos Papadopoulos, Lars Poulsen & 6 more Cansin Sackesen, Hugh Sampson, Alexandra Santos, Ronald Van Ree, Frans Timmermans, Aziz Sheikh

Original languageEnglish
JournalClinical and translational allergy
Issue number1
Publication statusPublished - 5 Jul 2016


  • Allergen immunotherapy for_DHAMI_Accepted 17May2016_GOLD VoR

    Allergen_immunotherapy_for_DHAMI_Accepted_17May2016_GOLD_VoR.pdf, 798 KB, application/pdf


    Final published version

    CC BY

    © 2016 Dhami et al. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License
    (, which permits unrestricted use, distribution, and reproduction in any medium,
    provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license,
    and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (
    publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

King's Authors



The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy.


We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesised.


The findings from this review will be used to inform the development of recommendations for EAACI’s Guidelines on AIT.

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